中国肿瘤生物治疗杂志2024，Vol.31Issue(1)：1-9,9.DOI:10.3872/j.issn.1007-385x.2024.01.001
肿瘤免疫细胞治疗:前景与挑战
Immune cell therapy for tumor:prospects and challenges
摘要
Abstract
Immune cell therapy has become a new therapeutic method for tumors by repairing the immune system and stimulating the immune function of patients,and it has been proved to have good safety and favorable therapeutic effects in some tumor patients.This paper focuses on the clinical safety and effectiveness of immune cell therapies including CAR-T cells,TCR-T cells,NK cells and TIL,etc.in tumor treatment at home and abroad in recent years.At the same time,from three aspects of technology,industrialization and policy,we put forward the key problems,challenges and corresponding solutions in the field of immune cell therapy in China,including the strengthening of original basic theoretical research,the application and transformation of new technologies,the standardization of cell product preparation and clinical research,the improvement of automated and industrialized cell production process systems,the guarantee of upstream products in the cell therapy industry,the cultivation and expansion of high-level scientific research and clinical research teams with strong innovation ability,and the establishment and improvement of policies,regulations and scientific supervision system that are compatible with the development of cell therapy technology.Solving of these problems can ensure the benign development of immune cell therapy in China.关键词
肿瘤/免疫细胞治疗/临床试验/安全性/有效性Key words
tumor/immune cell therapy/clinical trial/safety/effectiveness分类
医药卫生引用本文复制引用
施明,谢云波,王福生..肿瘤免疫细胞治疗:前景与挑战[J].中国肿瘤生物治疗杂志,2024,31(1):1-9,9.基金项目
国家自然科学基金(No.82070617) （No.82070617）
国家重点研发计划(No.2022YFC2304402) （No.2022YFC2304402）
