中国肿瘤生物治疗杂志2024，Vol.31Issue(1)：10-18,9.DOI:10.3872/j.issn.1007-385x.2024.01.002
肿瘤精准靶向免疫治疗的关键:T细胞受体抗原筛选技术
The key to precise targeted immunotherapy for tumors:T cell receptor antigen screening techniques
摘要
Abstract
Adoptive T cell therapy has shown promising prospects in solid tumors and is becoming a major focus in the field of cancer therapy.TCR-T therapy relies on the specific recognition of peptide-major histocompatibility complex(pMHC)by the T cell receptor(TCR),leading to the activation of anti-tumor immune response of adoptive T cells.Therefore,a comprehensive analysis of the information of antigens targeted by TCRs is crucial for improving the efficacy and safety of TCR-T therapy in clinical applications.However,the lack of rapid and high-throughput TCR antigen screening techniques has limited the development of TCR-T therapy.In recent years,with the rapid advancement of high-throughput sequencing technologies,mass spectrometry-based flow cytometry,and computational biology,researchers have developed various TCR antigen screening techniques to decipher the antigen-targeting information of TCRs.This review summarizes TCR antigen screening methods,categorizing them into antigen-directed screening methods,TCR-directed screening methods,and bidirectional screening methods,and systematically introduces their strengths and limitations.Moreover,it delves into the prospects of TCR antigen screening development and provides new insights into the future of this area.关键词
肿瘤/T细胞受体/抗原/TCR抗原筛选技术/TCR-T疗法Key words
tumor/T cell receptor(TCR)/antigen/TCR antigen screening/TCR-T therapy分类
医药卫生引用本文复制引用
朱润棣,李贵登..肿瘤精准靶向免疫治疗的关键:T细胞受体抗原筛选技术[J].中国肿瘤生物治疗杂志,2024,31(1):10-18,9.基金项目
国家自然科学基金(No.32270994,No.32300764) （No.32270994,No.32300764）
江苏省杰出青年基金(No.BK20211505) （No.BK20211505）
中国医学科学院医学健康前沿交叉研究专项(No.2023-I2M-QJ-019) （No.2023-I2M-QJ-019）
