中国中西医结合影像学杂志2024，Vol.22Issue(1)：45-50,6.DOI:10.3969/j.issn.1672-0512.2024.01.010
基于fMRI研究经筋疗法对健康人脑网络拓扑结构的影响
Effects of meridian sinew therapy on functional brain networks in healthy individuals by fMRI
摘要
Abstract
Objective:To analyze the topology of functional brain networks in healthy volunteers before and after meridian sinew therapy using BOLD-fMRI combined with graph theory methods to reveal the modulation mechanisms of brain neural networks by meridian sinew therapy.Methods:Forty-one healthy volunteers were recruited and randomly assigned to the myofascial-release with acupuncture group(21 cases)and the myofascial-release group(20 cases).Simple reaction time test,Schulte grid test,cranial MRI 3D-T1WI and BOLD data were collected before and after treatment.GRETNA software was used to construct functional brain networks and calculate topological parameters for intra-group and inter-group comparisons before and after treatment.Results:After treatment,the two groups showed an increase in responsiveness and attention.The myofascial-release with acupuncture group showed an increase in global efficiency(Eglob)and small-worldness(σ),and a decrease in clustering coefficients(Cp)and characteristic path length(Lp).The myofascial-release group showed an increase in Eglob and a decrease in Lp.The myofascial-release with acupuncture group also showed a reduced strength of one-neural circuit connections,including 86 edges and 73 nodes.Correlation analysis showed that Eglob,the normalized clustering coefficient(γ)and σ were negatively correlated with Schulte grid time,while Lp was positively correlated with Schulte grid time.Conclusions:Meridian sinew therapy can significantly reshape functional brain networks and optimize their information processing patterns,thereby enhancing volunteers'responsiveness and attention.Acupuncture,as an important component of meridian sinew therapy,can play a crucial role in the structural remodeling of functional networks,which may be the basis for its disease prevention role.关键词
中医/经筋理论/针刺/功能磁共振成象/图论/脑功能网络Key words
Traditional Chinese medicine/Meridian sinew theory/Acupuncture/Functional magnetic resonance imaging/Graph theory/Brain functional network引用本文复制引用
张耿标,郑鸿毅,庄佳燕,吴碧霞,李伟佳,吴京铧,郑文斌..基于fMRI研究经筋疗法对健康人脑网络拓扑结构的影响[J].中国中西医结合影像学杂志,2024,22(1):45-50,6.基金项目
省科技创新战略专项市县科技创新支撑(大专项+任务清单)项目(STKJ2023042) （大专项+任务清单）
广东省"新医科"教指委2023年教学改革项目(129) （129）
广东省基础与应用基础研究基金企业联合基金(2021A1515220112). （2021A1515220112）
