中国中医药信息杂志2024，Vol.31Issue(2)：6-10,5.DOI:10.19879/j.cnki.1005-5304.202307044
基于肿瘤相关巨噬细胞糖代谢重编程探讨胃癌"脾虚瘀毒"病机理论科学内涵
Exploration on Scientific Connotation of Pathogenesis Theory of Gastric Cancer"Spleen Deficiency and Stasis Toxin"Based on the Reprogramming of Glucose Metabolism in Tumor-associated Macrophages
摘要
Abstract
The pathogenesis theory of"spleen deficiency and stasis toxin"in gastric cancer holds that spleen is the source of generation and transformation of qi and blood,that spleen deficiency is the internal basis of disease and throughout the disease.Stasis toxin is based on spleen deficiency,which is the fundamental pathogenesis of gastric cancer.In the pathological process of gastric cancer,a variety of metabolic substances in tumor cells and tumor microenvironment,mainly glucose metabolic reprogramming,undergo metabolic changes to reconstruct the phenotype and function of tumor-related macrophages,which is consistent with the pathogenesis theory of"spleen deficiency and stasis toxin".Therefore,this article focused on the reprogramming of glucose metabolism in tumor microenvironment to drive the phenotypic remodeling of tumor-related macrophages,explored the scientific connotation of the pathogenesis theory of"spleen deficiency and stasis toxin"of gastric cancer,and provided references for the theoretical and clinical research on the treatment of gastric cancer by TCM.关键词
脾虚瘀毒/肿瘤微环境/肿瘤相关巨噬细胞/糖代谢重编程/胃癌/中医学Key words
spleen deficiency and stasis toxin/tumor microenvironment/tumor-associated macrophages/glycolytic reprogramming/gastric cancer/TCM分类
医药卫生引用本文复制引用
杨培培,黄雯洁,李秋蓉,王柳翔,牛晓涛,舒鹏..基于肿瘤相关巨噬细胞糖代谢重编程探讨胃癌"脾虚瘀毒"病机理论科学内涵[J].中国中医药信息杂志,2024,31(2):6-10,5.基金项目
国家自然科学基金(82374539) （82374539）
国家中医药管理局《中医药循证能力建设项目》(2019XZZX-ZL003) （2019XZZX-ZL003）
国家中医药管理局重大疑难疾病中西医临床协作试点项目(2018年) （2018年）
国家中医临床研究基地开放课题(JD2019SZ11) （JD2019SZ11）
江苏省中医药科技发展计划重点项目(ZD202214) （ZD202214）
江苏省研究生实践创新计划(SJCX23_0888) （SJCX23_0888）
