中国中医药信息杂志2024，Vol.31Issue(2)：64-69,6.DOI:10.19879/j.cnki.1005-5304.202303269
基于自主研发ACU&MOX-DATA平台探索腧穴功效特点研究
Exploration on Characteristics of Acupoint Efficacy Based on the Self-developed ACU&MOX-DATA Platform
摘要
Abstract
Objective To explore the effects of different acupoints,different target organs,and different interventions on acupoint efficacy based on ACU&MOX-DATA platform;To illustrate and visualize whether the above factors have the characteristics of"specific effect"or"common effect"of acupoint efficacy.Methods The multi-source heterogeneous data were integrated from the original omics data and public omics data.After standardization,differential gene analysis,disease pathology network analysis,and enrichment analysis were performed using Batch Search and Stimulation Mode modules in ACU&MOX-DATA platform under the conditions of different acupoints,different target organs,and different interventions.Results Under the same disease state and the same intervention,there were differences in effects among different acupoints;under the same disease state,the same acupoint and intervention,the responses produced by different target organs were not completely consistent;under the same disease state and acupoint,there were differences in effects among different intervention measures.Conclusion Based on the analysis of ACU&MOX-DATA platform,it is preliminary clear that acupoints,target organs,and interventions are the key factors affecting acupoint efficacy.Meanwhile,the above results have indicated that there are specific or common regulatory characteristics of acupoint efficacy.Applying ACU&MOX-DATA platform to analyze and visualize the critical scientific problems in the field of acupuncture and moxibustion can provide references for deepening acupoint cognition,guiding clinical acupoint selection,and improving clinical efficacy.关键词
腧穴功效/针灸干预方式/靶器官响应/多组学数据/异源数据分析Key words
acupoint efficacy/interventions of acupuncture and moxibustion/target organ response/multi-omics data/heterogeneous data analysis分类
医药卫生引用本文复制引用
李思慧,余曙光,吴巧凤,刘书庆,唐强,张瑞斌,陈伟,洪浩,朱冰梅,蓝勋,王勇..基于自主研发ACU&MOX-DATA平台探索腧穴功效特点研究[J].中国中医药信息杂志,2024,31(2):64-69,6.基金项目
国家重点研发计划(2022YFC3500703、2019YFC1709001) （2022YFC3500703、2019YFC1709001）
国家自然科学基金(82174512) （82174512）
国家中医药管理局中医药创新团队及人才支持计划(ZYYCXTD-D-202003) （ZYYCXTD-D-202003）
四川省重大科技专项(2022ZDZX0033) （2022ZDZX0033）
成都中医药大学杏林学者青年创新团队项目(QNTD2022003) （QNTD2022003）
