中国中医药信息杂志2024，Vol.31Issue(2)：154-159,6.DOI:10.19879/j.cnki.1005-5304.202303248
清肝散结消瘿方治疗桥本甲状腺炎的疗效及初步机制研究
Study on Efficacy and Preliminary Mechanism of Qinggan Sanjie Xiaoying Decoction in the Treatment of Hashimoto's Thyroiditis
摘要
Abstract
Objective To explore the clinical efficacy and mechanism of Qinggan Sanjie Xiaoying Decoction in the treatment of Hashimoto's thyroiditis with syndrome of stagnation heat of liver meridian and stagnation of spleen deficiency and phlegm.Methods Totally 70 patients were divided into control group and medicine group according to their wishes,with 35 patients in each group.Both groups were restricted to an iodine diet.The medicine group was given Qinggan Sanjie Xiaoying Granules,1 sachet at a time,twice a day,orally.The treatment for both groups lasted for 4 weeks.20 healthy people were chosen as the healthy group.The clinical efficacy of both groups was observed.TCM symptom score,thyroid antibody titer levels(TPOAb,TGAb),changes in thyroid volume and isthmus of both groups before and after treatment were compared.Levels of serum IKKα,IKBα and TNF-α of the three groups were compared.Adverse reactions of patients daring the treatment period were monitored.Results The total effective rate of the medicine group was 85.71%(30/35),while the control group was 20.00%(7/35).The medicine group was superior to the control group(P<0.05).Compared with before treatment,the medication group showed significant improvement in TCM symptom scores,TPOAb and TGAb titer levels,thyroid volume,and thyroid isthmus thickness after treatment(P<0.05).After treatment,TCM symptom score,thyroid volume in the medicine group were lower than those in the control group(P<0.05),and the decrease rate of TPOAb titer was higher than that in the group(P<0.05).The levels of IKKα and TNF-α before treatment of medicine group and control group were higher than that in the healthy control group,and the level of IKBα was lower than that of the healthy control group(P<0.05);compared with before treatment,the levels of IKKα and TNF-α in the medicine group decreased,and the level of IKBα increased(P<0.05);after treatment,the levels of IKKα and TNF-α in the medicine group were lower than that in the control group,and IKBα was higher than the control group(P<0.05).No adverse events were observed during the treatment period in both groups of patients.Conclusion Qinggan Sanjie Xiaoying Decoction can reduce the antibody titer level,thyroid enlargement,isthmus thickness,and TCM syndrome score in the treatment of Hashimoto's thyroiditis.It is safe and effective in clinical practice.Qinggan Sanjie Xiaoying Decoction may play a therapeutic role by interfering with NF-κB signaling pathway.关键词
桥本甲状腺炎/清肝散结消瘿方/临床疗效/机制/中医药Key words
Hashimoto's thyroiditis/Qinggan Sanjie Xiaoying Decoction/clinical efficacy/mechanism/TCM分类
医药卫生引用本文复制引用
李心爱,丁治国,陈晓珩,李哲,祁烁..清肝散结消瘿方治疗桥本甲状腺炎的疗效及初步机制研究[J].中国中医药信息杂志,2024,31(2):154-159,6.基金项目
陕西省中医药管理局科研项目(2021-GJ-LC002) （2021-GJ-LC002）
铜川市甲状腺病防治中心科研项目(TJF-2022-25) （TJF-2022-25）
北京中医药大学孙思邈研究院青年培优项目(SSMYJY-3-2021-13) （SSMYJY-3-2021-13）
