中国中医药信息杂志2024，Vol.31Issue(2)：191-196,6.DOI:10.19879/j.cnki.1005-5304.202302082
基于PI3K/AKT信号通路中医药改善溃疡性结肠炎机制研究进展
Research Progress of TCM in Improving Ulcerative Colitis Based on PI3K/AKT Signaling Pathway
摘要
Abstract
Ulcerative colitis(UC)is a common disease of the digestive system.Phosphatidylinositol-3-kinase(PI3K)/synuclein/threonine kinase(AKT)is closely related to cell survival,apoptosis,inflammation and other biological processes,and the expression levels of PI3K and AKT significantly increase during the course of UC,with accelerated apoptosis,improved inflammation,and damaged intestinal mucosal barrier function.In recent years,a large number of basic and clinical trials have been conducted on PI3K/AKT signaling pathway in TCM,and the results indicate that PI3K/AKT signaling pathway is expected to be an important potential target for UC treatment.This article analyzed the mechanism of the regulation of PI3K/AKT signaling pathway in TCM from monomer,extract,compound and acupuncture,and suggested that the regulation of this signaling pathway is of great significance for the prevention and treatment of UC,and provide reference for drug development.关键词
中医药/PI3K/AKT信号通路/溃疡性结肠炎/综述Key words
TCM/PI3K/AKT signaling pathway/ulcerative colitis/review分类
医药卫生引用本文复制引用
舒郁平,余丹琪,荣越,陶弘武,柳越冬..基于PI3K/AKT信号通路中医药改善溃疡性结肠炎机制研究进展[J].中国中医药信息杂志,2024,31(2):191-196,6.基金项目
国家自然科学基金面上项目(82074449) （82074449）
