中华骨质疏松和骨矿盐疾病杂志2023，Vol.16Issue(5)：436-443,8.DOI:10.3969/j.issn.1674-2591.2023.05.003
新型冠状病毒感染对骨质疏松症患者骨代谢的影响
Effect of coronavirus disease 2019 on bone metabolism in patients with osteoporosis
摘要
Abstract
Objective To analyze the effect of coronavirus disease 2019(COVID-19)on bone metabolism in patients with osteoporosis.Methods A retrospective analysis was performed on 98 patients with osteoporosis who were di-agnosed with COVID-19 and attended Shanghai General Hospital from November 2022 to March 2023.We uniformly recor-ded bone metabolic markers and positive duration of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),medication history(history of anti-osteoporosis drugs,calcium or vitamin D withdrawal and steroids application during SARS-CoV-2 positive time,and history of underlying medical conditions and vaccinations.SPSS.26 was used for statistical analysis.Results Serum bone gla protein(BGP)and type 1 procollagen amino-terminal peptide(P1NP)levels[9.915(8.260,11.873)μg/L and 20.250(15.080,28.930)μg/L]were lower in patients with osteoporosis after infection with SARS-CoV-2 than before infection[10.365(8.395,29.3150)μg/L and 22.135(16.330,33.085)μg/L](both P＜0.01).The change in serum 25 hydroxyvitamin D(25OHD)levels[4.155(-0.135,15.078)nmol/L]was greater in patients with osteoporosis who stopped taking calcium or vitamin D than in patients with osteoporo-sis who did not stop taking calcium or vitamin D[-0.485(-8.465,8.695)nmol/L](P＜0.05).The changes in ser-um bone alkaline phosphatase(BAP)were greater in osteoporosis patients taking steroids[1.520(1.320,6.190)μg/L]than in osteoporosis patients not taking steroids[0.370(-0.950,1.270)μg/L](P＜0.05).Duration of SARS-CoV-2 positive was not significantly correlated with serum 25OHD levels and 25OHD changes before and after infection.Conclusion COVID-19 depresses bone formation in patients with osteoporosis,and serum BGP and P1NP levels are reduced compared to pre-infection levels.Serum 25OHD level in osteoporotic patients is not significantly correlated with COVID-19.关键词
骨质疏松症/新型冠状病毒感染/骨代谢Key words
osteoporosis/COVID-19/bone metabolism分类
医药卫生引用本文复制引用
朱小楠,陈琳,潘凌,沈佳敏,彭永德,王育璠,游利..新型冠状病毒感染对骨质疏松症患者骨代谢的影响[J].中华骨质疏松和骨矿盐疾病杂志,2023,16(5):436-443,8.基金项目
国家重点研发计划(2021YFC25017001) （2021YFC25017001）
上海老龄化和妇儿健康研究专项(2020YJZX0104) （2020YJZX0104）
