中华骨质疏松和骨矿盐疾病杂志2023，Vol.16Issue(5)：444-449,6.DOI:10.3969/j.issn.1674-2591.2023.05.004
绝经后女性血脂水平紊乱与骨代谢和骨密度的相关性
Correlation between dyslipidemia and bone metabolism and bone mineral density in postmenopausal women
摘要
Abstract
Objective To investigate the connection between various lipid indices and bone metabolism and bone mineral density at diverse sites in postmenopausal women with dyslipidemia.Methods Information was collected on 121 female patients who fulfilled the eligibility requirements for the study,including their age,body mass index(BMI),lipid indices[total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)],markers of bone metabolism osteocalcin,type 1 procollagen ami-no-terminal peptide(P1NP),and β-cross-linked C-telopeptide of typeⅠ collagen(β-CTX),and bone mineral den-sity(BMD)at various sites.Spearman rank correlation analysis and multiple linear regression were employed in order to investigate the connections between lipid indices,bone metabolic biomarkers,and BMD at different sites.Results In dyslipidemic women,Spearman correlation analysis revealed low inverse correlation between TC and P1NP(r=-0.45,P＜0.001),low negative correlations between lumbar spine(r=-0.31,P＜0.001)and femoral neck BMDs(r=-0.24,P=0.007).Negative interaction with P1NP(r=-0.21,P=0.023).The results of multiple linear regression analysis revealed a significant relation between TC and lumbar spine BMD in addition to a negative correlation between the two(β=-0.432,P＜0.001).Conclusion The results of the data analysis showed a correlation between elevated TC and LDL-C levels and reduced osteogenesis in postmenopausal women with dyslipidemia,and a strong association between TC and reduced BMD in the lumbar spine,while no significant correlation of TG and HDL-C on BMD at any site was found in this study.关键词
绝经后妇女/血脂紊乱/骨代谢标志物/骨密度Key words
postmenopausal women/dyslipidemia/bone turnover markers/bone mineral density分类
医药卫生引用本文复制引用
张友芳,赵长伟..绝经后女性血脂水平紊乱与骨代谢和骨密度的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2023,16(5):444-449,6.基金项目
国家重点研发计划项目(2019YFC1709905) （2019YFC1709905）
赵文海全国名老中医药专家传承工作(202205) （202205）
