中华骨质疏松和骨矿盐疾病杂志2023，Vol.16Issue(5)：514-520,7.DOI:10.3969/j.issn.1674-2591.2023.05.014
废用性骨质疏松症的发病机制及治疗
Pathogenesis and treatment of disuse osteoporosis
摘要
Abstract
There is no consensus on the pathogenesis and treatment of disuse osteoporosis(DOP)both do-mestically and internationally,and there are many viewpoints on its pathogenesis and treatment.DOP has gradually become a major public health issue,bringing a great burden to people's lives.This article summarizes and analyzes the pathogenesis of DOP by reviewing relevant literature both domestically and internationally in recent years.The in-hibition of Wnt/β-catenin signal pathway,imbalance of osteoclastogenesis inhibitory factor(OPG)/receptor activa-tor of nuclear factor kappa-B ligand(RANKL)ratio,change in mechanical load,effects of muscle factors on bone cells,and the mechanisms and effects of related therapeutic drugs on DOP.The results of this review indicate that the pathogenesis of DOP is mainly caused by the above factors,but the molecular mechanism mainly characterized by mechanical load changes has not been fully elucidated.Drug therapy has the singularity of stimulating osteogenesis and inhibiting osteoclasis,and has side effects.The optimal combination of physical therapy and drug therapy has not been demonstrated.关键词
废用性骨质疏松/机械负荷/Wnt/β-catenin信号通路/OPG/RANKL通路Key words
disuse osteoporosis/mechanical load/Wnt/β-Catenin signaling pathway/OPG/RANKL pathway分类
医药卫生引用本文复制引用
李庆伟,田志康,孟纯阳..废用性骨质疏松症的发病机制及治疗[J].中华骨质疏松和骨矿盐疾病杂志,2023,16(5):514-520,7.基金项目
济宁市科技局课题(2023YXNS039) （2023YXNS039）
