神经药理学报2023，Vol.13Issue(4)：1-7,7.DOI:10.3969/j.issn.2095-1396.2023.04.001
基于网络药理学分析独活寄生汤治疗椎间盘退变的分子机制
Cyberpharmacology-Based Analysis of the Molecular Mechanism of Dokuto Parasite Soup in the Treatment of Intervertebral Disc Degener-ation
摘要
Abstract
Objective:To analyze the possible mechanism of action of Dokuto parasite soup in the treatment of intervertebral disc degeneration(IDD)using network pharmacology.Methods:The bioactive components of Dokuto parasite soup were searched in the TCMSP platform and screened according to the research needs,while the targets of intervertebral disc degeneration were searched in the GeneCards and OMIM databases;the"drug compo-nent-target-disease"complex network was constructed using Cytoscape software.A complex network of"drug component-target-disease"was constructed using Cytoscape software,and a Wayne diagram was constructed to obtain the targets for IDD treatment with Dokuto para-site soup.Results:A total of 240 active ingredients,257 potential targets,and 2 713 targets of intervertebral disc degeneration disease were explored in Dokuto parasite soup,and 75 com-mon targets were obtained.20 entries were obtained from GO enrichment analysis and 20 en-tries from KEGG pathway enrichment analysis.Conclusion:The herbal formula Dokuto para-site soup may potentially inhibit inflammation and regulate cell apoptosis for the treatment of intervertebral disc degeneration.This is achieved by modulating various targets such as MAPK3,FOS,RELA,TP53,IL-6,MAPK1,TNF,to regulate signaling pathways inclu-ding advanced glycation end product-receptor for advanced glycation end products(AGE-RAGE),TNF,IL-17,and PI3K-Akt.关键词
独活寄生汤/椎间盘退变/作用机制/网络药理学/靶点/信号通路Key words
Dokuto parasite soup/intervertebral disc degeneration/mechanism of ac-tion/network pharmacology/targets/signaling pathways分类
医药卫生引用本文复制引用
陶瑜晶,王想福,谢芋涛,陈伟国,赵恒,张万乾,杨焕莹,杨建霞,任毅..基于网络药理学分析独活寄生汤治疗椎间盘退变的分子机制[J].神经药理学报,2023,13(4):1-7,7.基金项目
兰州市科技发展计划项目(No.2020-ZD-36) （No.2020-ZD-36）
兰州市人才创新创业项目(No.2020-RC-54) （No.2020-RC-54）
甘肃省自然科学基金项目(No.21JR1RA058) （No.21JR1RA058）
