中国现代医生2024，Vol.62Issue(2)：26-28,3.DOI:10.3969/j.issn.1673-9701.2024.02.006
错配修复蛋白3在口腔鳞状细胞癌中的表达及意义
Expression of MutS homolog 3 in oral squamous cell carcinoma and its significance
摘要
Abstract
Objective To investigate the expression of MutS homolog 3(MSH3)in oral squamous cell carcinoma and its significance.Methods The MSH3 protein expression was examined by immunohistochemistry in 20 normal oral mucosa and 60 oral squamous cell carcinoma tissues.Results Our results showed that MSH3 expression in oral squamous cell carcinoma tissues was lower than normal oral mucosa.The MSH3 expression in oral squamous cell carcinoma tissues with better differentiation was higher than that with worse differentiation.The positive MSH3 expression decreased from oral squamous cell carcinoma patients without lymph nodal metastasis to that with metastasis.MSH3 expression was not related to the patients'gender,age,tumour location or size.Conclusion Downregulation of MSH3 is consistent with poorly differentiation and nodal metastasis in oral squamous cell carcinoma.MSH3 may play a significant role in the malignant progression of oral squamous cell carcinoma.关键词
错配修复蛋白3/口腔鳞状细胞癌/免疫组化/分化程度/转移Key words
MutS homolog 3/Oral squamous cell carcinoma/Immunohistochemistry/Differentiation/Metastasis分类
医药卫生引用本文复制引用
修小斐,高峰,王晓梅,徐嘉曼,肖雪兰,王大维..错配修复蛋白3在口腔鳞状细胞癌中的表达及意义[J].中国现代医生,2024,62(2):26-28,3.基金项目
河北省财政厅资助临床医学优秀人才培养项目 （）
