中国中西医结合杂志2024，Vol.44Issue(1)：37-43,7.DOI:10.7661/j.cjim.20231016.336
托里消毒散与柴胡清肝汤干预热盛肉腐证化脓性非哺乳期乳腺炎初期的随机对照研究
Comparison of Clinical Efficacy of Tuoli Xiaodu Powder and Chaihu Qinggan Decoction in Treatment of Non-puerperal Mastitis patients with Intense Heat Induced Flesh Decay Syndrome at Early Stage of Abscess:A Randomized Controlled Trial
摘要
Abstract
Objective To compare the clinical efficacy of Tuoli Xiaodu Powder(TLXDP)and Chaihu Qinggan Decoction(CHQGD)in the treatment of non-puerperal mastitis(NPM)patients with intense heat induced flesh decay syndrome(IHIFDS)at the early stage of abscess and their effects on the levels of relevant serum inflammatory indices.Methods A randomized,controlled,single-blind study method was used.Seventy-two early stage NPM patients with IHIFDS at the outpatient clinic were randomly assigned to the test group and the control group,36 in each group.Patients in the test group took TLXDP and those in the control group took CHQGD.The treatment course lasted for 28 days.Fasting blood was collected at early morning on the first,14th and 28th day of grouping.The size of the mass was also measured,and the degree of abscess formation and skin breakdown were recorded as well.Results The number and extent of abscess cavities were greater in the test group on the 14th day of treatment,and the number and extent of surface ulceration of abscesses were more severe(P＜0.05).On the 28th day of treatment the masses in the test group were significantly smaller than those in the control group(P＜0.05).Post-treatment abnormally increased erythrocyte sedimentation rate(ESR)decreased to a better level in the test group than in the control group(P＜0.05).Immune dysfunction in early stage NPM patients was manifested by abnormally increased immunoglobulin G(IgG),complement 4(C4),CD3+T lymphocytes(CD3+),CD4+T lymphocytes(CD4+),regulatory T cells(Treg),and CD19+B lymphocytes(CD19+),and abnormally decreased complement 3(C3),human leucocyte antigen DR(HLA-DR),and natural killer cell(NK).All abnormal parameters tended to be normal after treatment.The regulatory effect on HLA-DR T cells was stronger in the test group(P＜0.05).Conclusion Compared with CHQGD,TLXDP was better in promoting mass reduction,anti-inflammation,and immunomodulation in the treatment of early stage NPM.关键词
化脓性非哺乳期乳腺炎初期/托里消毒散/柴胡清肝汤/热盛肉腐证/随机对照试验/中药复方Key words
non-puerperal mastitis at the early stage of abscess/Tuoli Xiaodu Powder/Chaihu Qinggan Decoction/intense heat induced flesh decay syndrome/randomized controlled trial/Chinese herbal compound引用本文复制引用
杜楠楠,万华,冯佳梅,瞿文超,邵士珺,孙佳晔,吴雪卿..托里消毒散与柴胡清肝汤干预热盛肉腐证化脓性非哺乳期乳腺炎初期的随机对照研究[J].中国中西医结合杂志,2024,44(1):37-43,7.基金项目
上海市卫生健康委员会科研课题计划项目(No.202040254) （No.202040254）
