中医药信息2024，Vol.41Issue(1)：32-35,43,5.DOI:10.19656/j.cnki.1002-2406.20240106
关苍术亲脂性化学成分研究
Study on Lipophilic Chemical Constituents of Atractylodes japonica
摘要
Abstract
Objective:To study the lipophilic chemical constituents of Atractylodes japonica.Methods:The chemical constituents of Atractylodes japonica were isolated and purified through the methods such as silica gel column chromatography,Sephadex LH-20 column chromatography,medium pressure liquid chromatography,and semi-preparative HPLC;and the structural identification of the components was conducted through physicochemical properties and MS and NMR spectroscopy techniques.Results:Twelve compounds were isolated and identified from Atractylodes japonica,which are osthol(1),atractylochromene(2),6,7-dihydroxy-8-methoxycoumarin(3),8-hydroxy-6,7-dimethoxycoumarin(4),7-methoxycoumarin(5),stigmast-4-en-3-one(6),taraxeryl acetate(7),atractylenolide Ⅱ(8),atractylenolide Ⅰ(9),eucalyptus-4(15)-ene-7β,11-diol(10),methyl 4-hydroxycinnamate(11),syringaldehyde(12).Conclusion:Compounds 1,3-6,10-12 are the first isolated compounds from Atractylodes japonica.关键词
关苍术/化学成分/理化性质/分离鉴定/结构鉴定Key words
Atractylodes japonica/Chemical constituents/Physical and chemical properties/Isolation and identification/Structural identification引用本文复制引用
周媛媛,孙杰,江冰悦,杨咏琪,董柯杉,王萍,方振兴,张晓娟..关苍术亲脂性化学成分研究[J].中医药信息,2024,41(1):32-35,43,5.基金项目
黑龙江省自然科学基金项目(LH2019H048) （LH2019H048）
黑龙江省"头雁"团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号) （黑龙江省头雁行动领导小组文件[2019]5号）
黑龙江省博士后科研启动金资助项目(LBH-Q16207) （LBH-Q16207）
黑龙江省大学生创新创业训练计划项目(S202310228067) （S202310228067）
黑龙江中医药大学新药研究基金(2018xy02) （2018xy02）
