动物营养学报2023，Vol.35Issue(12)：7541-7551,11.DOI:10.12418/CJAN2023.684
鱼源抗菌肽的分子设计与优化策略及其应用研究进展
Research Progress in Molecular Design and Optimization Strategies of Fish-Derived Antimicrobial Peptides and Their Applications
摘要
Abstract
Antimicrobial peptides are the most promising antibiotic alternatives because of their broad-spectrum antimicrobial properties,thermal stability,and no resistance.However,poor activity,high toxicity and expen-sive synthesis of natural antimicrobial peptides have limited their further application.In recent years,the molec-ular modification and design of natural antimicrobial peptides have become a hot research topic for scholars at home and abroad.Fish is an important source of natural antimicrobial peptides,and this study extensively re-viewed the mechanism of action,molecular design and optimization strategies of fish-derived antimicrobial pep-tides and their applications in aquaculture in recent years,which is aiming to provide a comprehensive under-standing and knowledge of antimicrobial peptides and provide new ideas for developing and applying antimicro-bial peptides.[Chinese Journal of Animal Nutrition,2023,35(12):7541-7551]关键词
抗菌肽/分子设计与优化/作用机制/应用Key words
antimicrobial peptides/molecular design and optimization/mechanism of action/application分类
农业科技引用本文复制引用
吴迪,王连生..鱼源抗菌肽的分子设计与优化策略及其应用研究进展[J].动物营养学报,2023,35(12):7541-7551,11.基金项目
中央级公益性科研院所基本科研业务费专项(HSY202206Q,2022XT0402) （HSY202206Q,2022XT0402）
财政部和农业农村部-国家现代农业产业技术体系 （）
黑龙江省自然科学基金(LH-2023C056) （LH-2023C056）
黑龙江省博士后基金(LBH-Z22297) （LBH-Z22297）
虹鳟鱼病害免疫防控技术研发及应用(JD22A017) （JD22A017）
