福建农业科技2023，Vol.54Issue(11)：36-43,8.DOI:10.13651/j.cnki.fjnykj.2023.11.006
D-海藻糖联合氨基糖苷类抗生素杀菌效果分析
Analysis of the Bactericidal Effect of D-trehalose Combined with Aminoglycoside Antibiotics
摘要
Abstract
At present,the development of antibiotic adjuvants to improve the bactericidal effect of traditional antibiot-ics is one of the effective ways to solve the bacterial resistance.In order to find the new antibiotic adjuvants,the kill-ing tests of Escherichia coli BW25113 and Staphylococcus aureus A TCC25923 were carried out through the exoge-nous addition of D-trehalose and three major types of bactericidal antibiotics,and the potential bactericidal mechanism of D-trehalose combined with aminoglycoside antibiotics was explored by the exogenous addition of carbonyl cyanide m-chlorophenylhydrazone(CCCP)in the combined group of D-trehalose and aminoglycoside antibiotics.The results showed that D-trehalose combined with aminoglycoside antibiotics had the best killing efficacy onEscherichia coli and Staphylococcus aureus.After the exogenous addition of CCCP in the combined sterilization group,the bacteria could restore the tolerance phenotype.It was indicated that D-trehalose was expected to be used as a new antibiotic adju-vant,suggesting that the antibacterial mechanism of D-trehalose combined with aminoglycoside antibiotics was related to the proton motive force.关键词
D-海藻糖/氨基糖苷类抗生素/大肠杆菌/金黄色葡萄球菌Key words
D-trehalose/Aminoglycoside antibiotics/Escherichia coli/Staphylococcus aureus分类
生物科学引用本文复制引用
赖泽迎,吴泽源,杨晓乐,陈雅娟..D-海藻糖联合氨基糖苷类抗生素杀菌效果分析[J].福建农业科技,2023,54(11):36-43,8.基金项目
福建省自然科学基金面上项目(2019J01278). （2019J01278）
