发育医学电子杂志2024，Vol.12Issue(1)：25-29,5.DOI:10.3969/j.issn.2095-5340.2024.01.005
肺表面活性物质蛋白-B缺陷与足月新生儿呼吸窘迫综合征的相关性研究
Research on the correlation between pulmonary surfactant protein B deficiency and neonatal respiratory distress syndrome in full-term newborns
摘要
Abstract
Objective To explore the correlation between pulmonary surfactant protein(SP)-B deficiency and neonatal respiratory distress syndrome(NRDS)in full-term newborns.Method From July 2019 to June 2023,research was conducted in the Seventh Medical Center of PLA General Hospital and the other three hospitals.60 full-term newborns who died with NRDS were included in the NRDS group.The control group included 60 full-term newborns with non-NRDS who died after surgery due to other reasons during the same period.Chest X-ray results were collected.Within 30 min after the newborns died,bronchoalveolar lavage and lung tissue sampling were performed.SP-B expression was detected using Western blotting.Chi-square test was used for statistical methods.Result Newborns in the NRDS group experienced severe hypercapnia and hypoxemia after birth.Adopting comprehensive treatment measures such as exogenous pulmonary surfactant,invasive high-frequency oscillatory ventilation respiratory support,nitric oxide therapy to reduce pulmonary arterial hypertension,etc.Ten cases received extracorporeal membrane oxygenation(ECMO).However,all of them died.Chest X-rays in the NRDS group all showed white lungs.The proportion of positive expression of SP-B monomers(molecular weight 8 ku)and dimers(molecular weight 16-18 ku)in bronchoalveolar lavage fluid of newborns in the NRDS group was significantly lower than that in the control group[8 ku:75.0%(45/60)vs 100.0%(60/60),χ2=17.143;16-18 ku:73.3%(44/60)vs 100.0%(60/60),χ2=18.462;P<0.001].The proportion of positive expression of SP-B monomers and dimers in lung tissue of the NRDS group was significantly lower than that of the control group[8 ku:75.0%(45/60)vs 100.0%(60/60),χ2=17.143;16-18 ku:70.0%(42/60)vs 100.0%(60/60),χ2=21.176;P<0.001].Fifteen newborns with SP-B deficiency were detected in the NRDS group,while one with SP-B deficiency was detected in the control group.The proportion of SP-B deficiency in the NRDS group was significantly higher than that in the control group[25.0%(15/60)vs 1.7%(1/60),χ2=14.135,P<0.001].Conclusion SP-B deficiency is corrected with NRDS in full-term newborns to some extent.关键词
足月新生儿/呼吸窘迫综合征/肺表面活性物质蛋白-B/缺陷/遗传Key words
Full-term newborn/Respiratory distress syndrome/Surfactant protein B/Deficiency/Inheritance引用本文复制引用
尹晓娟,李明霞,史源,梅花,张晓媛,朱艳萍,霍梦月,封志纯..肺表面活性物质蛋白-B缺陷与足月新生儿呼吸窘迫综合征的相关性研究[J].发育医学电子杂志,2024,12(1):25-29,5.基金项目
国家自然科学基金(30871397) （30871397）
