发育医学电子杂志2024，Vol.12Issue(1)：61-67,74,8.DOI:10.3969/j.issn.2095-5340.2024.01.011
哺乳动物合子基因激活时期染色体的表观遗传学变化
Epigenetic changes in chromosomes during zygotic gene activation in mammals
王鑫宇 1杨烨 1赵纯 1凌秀凤1
作者信息
- 1. 南京医科大学附属妇产医院 南京市妇幼保健院生殖医学中心,江苏 南京 211112
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摘要
Abstract
After fertilization in mammals,the embryo gradually changes from maternal factor regulation to zygotic regulation,expressing zygotic transcripts,namely zygotic gene activation(ZGA).Dramatic epigenetic changes occur,such as histone modification,DNA methylation reprogramming and chromatin remodeling.Abnormalities in epigenetic remodeling can lead to severe developmental defects and even embryo death.Therefore,understanding the epigenetic changes in the ZGA transcripts is crucial to elucidate their pathogenic mechanisms.In this review,the recent advances in DNA methylation reprogramming,histone modification and chromatin remodeling during the activation of mammalian zygotic genes are reviewed in order to provide references for further investigation of the epigenetic changes of chromosomes during the activation of mammalian zygotic genes.关键词
合子基因激活/染色质重塑/组蛋白/甲基化/表观遗传学Key words
Zygotic gene activation/Chromatin remodeling/Histone/Methylation/Epigenetics引用本文复制引用
王鑫宇,杨烨,赵纯,凌秀凤..哺乳动物合子基因激活时期染色体的表观遗传学变化[J].发育医学电子杂志,2024,12(1):61-67,74,8.
