国际生殖健康/计划生育杂志2024，Vol.43Issue(1)：32-37,6.DOI:10.12280/gjszjk.20230330
多囊卵巢综合征患者卵巢颗粒细胞胰岛素抵抗的相关信号通路
Pathways of Insulin Resistance in Ovarian Granulosa Cells of Polycystic Ovary Syndrome Patients
摘要
Abstract
Insulin resistance(IR)is associated with the genesis and development of polycystic ovary syndrome(PCOS).The abnormity of insulin-related signaling pathways causes metabolism disorder,which affects follicle development and quality.In ovarian granulosa cells of PCOS,the classical pathways of insulin include phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)and mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK).The pathways related with inflammation include Toll-like receptor(TLR)/nuclear factor-κB(NF-κB),and the pathways of oxidative stress include nuclear factor-erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)and GTPase of immunity-associated protein 7(GIMAP7)/sonic hedgehog(SHH).There are multiple pathways related with metabolism,such as the lipid metabolism-related pathway of activating transcription factor 4(ATF4).Therefore,clarifying the IR-related signal transduction pathway and molecular mechanism in ovarian granulosa cells of PCOS patients can supplement the knowledge of PCOS pathogenesis,and further provide new ideas for the treatment of PCOS.关键词
多囊卵巢综合征/胰岛素抵抗/细胞内信号肽和蛋白质类/信号传导/颗粒细胞Key words
Polycystic ovary syndrome/Insulin resistance/Intracellular signaling peptides and proteins/Signal transduction/Granulosa cells引用本文复制引用
任露露,任文超,张晓轩,任春娥..多囊卵巢综合征患者卵巢颗粒细胞胰岛素抵抗的相关信号通路[J].国际生殖健康/计划生育杂志,2024,43(1):32-37,6.基金项目
山东省医药卫生科技发展计划项目(202005030464) （202005030464）
