国际生殖健康/计划生育杂志2024，Vol.43Issue(1)：38-42,5.DOI:10.12280/gjszjk.20230372
多囊卵巢综合征中翻译后修饰的研究进展
Research Progress on Post-Translational Modification in Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders in women,but its pathogenesis is unknown.Current researches suggested that the disease may be influenced by a variety of factors,including epigenetic and environmental factors.In recent years,the incidence of PCOS has been increasing,leading to a decline in the quality of life of patients.Therefore,it is necessary to actively explore new treatments.Post-translational modification(PTM)is an important way to regulate protein function.Most studies have found that phosphorylation is closely related to insulin resistance of PCOS,acetylation is mainly focused on the quality of PCOS oocytes,and methylation is closely related to PCOS lipid metabolism.Exploring the role of PTM in the occurrence and development of PCOS may provide new ideas for targeted treatment of this disease.关键词
多囊卵巢综合征/蛋白质加工,转译后/磷酰化/乙酰化作用/甲基化/泛素化Key words
Polycystic ovary syndrome/Protein processing,post-translational/Phosphorylation/Acetylation/Methylation/Ubiquitination引用本文复制引用
刘一燃,冯睿芝,钱云..多囊卵巢综合征中翻译后修饰的研究进展[J].国际生殖健康/计划生育杂志,2024,43(1):38-42,5.基金项目
国家自然科学基金(81971451) （81971451）
江苏省"双创团队"项目(JSSCTD202144) （JSSCTD202144）
