国际生殖健康/计划生育杂志2024，Vol.43Issue(1)：53-57,5.DOI:10.12280/gjszjk.20230410
内质网应激在多囊卵巢综合征中的研究进展
Advances of Endoplasmic Reticulum Stress in Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS)is a prevalent gynecological endocrine disorder characterized by menstrual disorders,infertility,hirsutism,acne and obesity.The precise pathogenesis of PCOS remains unclear.Recent evidence has demonstrated the involvement of endoplasmic reticulum stress in its pathological process,suggesting the potential of endoplasmic reticulum stress as a novel therapeutic target for PCOS.Endoplasmic reticulum stress refers to the state where the endoplasmic reticulum is in a state of steady imbalance and the accumulation of incorrectly folded or unfolded proteins in the endoplasmic reticulum.Moderate endoplasmic reticulum stress contributes to the development and maturation of follicles.Sustained endoplasmic reticulum stress leads to the abnormal follicle development,hormonal and insulin synthesis and secretion disorders in PCOS patients by inducing granulosa cell apoptosis and mediating processes such as steroid hormone metabolism,glucose metabolism and lipid metabolism,thereby impairing female fertility.This paper provides an overview of the relationship between endoplasmic reticulum stress and various pathogenic factors associated with PCOS,to offer fresh insights into its etiology and treatment.关键词
多囊卵巢综合征/内质网应激/卵泡发育/雄激素增多症/胰岛素抵抗/肥胖症Key words
Polycystic ovary syndrome/Endoplasmic reticulum stress/Follicular development/Hyperandrogenism/Insulin resistance/Obesity引用本文复制引用
李文雅,张巧利,杨晓葵..内质网应激在多囊卵巢综合征中的研究进展[J].国际生殖健康/计划生育杂志,2024,43(1):53-57,5.基金项目
北京市医院管理中心"登峰"人才培养计划(DFL20191401) （DFL20191401）
