国际生殖健康/计划生育杂志2024，Vol.43Issue(1)：74-78,5.DOI:10.12280/gjszjk.20230334
铜死亡在妇科恶性肿瘤中的研究进展
Research Progress of Cuproptosis in Gynecologic Malignant Tumor
摘要
Abstract
Copper ion as an important coenzyme participates in a wide range of metabolic processes,including aerobic respiration,peptide amidation,iron transport,superoxide dismutase and extracellular matrix biosynthesis.Copper homeostasis is an important mechanism to maintain cell activity.Cuproptosis is a form of cell death caused by the accumulation of copper ions,which is characterized by the imbalance of copper homeostasis,the accumulation of copper in cells,the selective disturbance of tricarboxylic acid cycle,the aggregation of fatty acylated mitochondrial enzymes and the loss of iron-sulfur protein,the protein stress of mitochondria,the cell membrane cracking,and finally the cell death.Gynecological malignant tumors are important causes of cancer death in women.It is found that cuproptosis is closely related to the occurrence,development,prognosis and drug resistance of gynecological malignant tumors.Some cuproptosis regulators can inhibit tumor metastasis and recurrence by inhibiting angiogenesis and regulating drug resistance of cancer cells.Therefore,cuproptosis is a valuable research direction for the treatment of gynecological malignant tumors.关键词
铜/线粒体/卵巢肿瘤/宫颈肿瘤/子宫内膜肿瘤/铜死亡Key words
Copper/Mitochondria/Ovarian neoplasms/Uterine cervical neoplasms/Endometrial neoplasms/Cuproptosis引用本文复制引用
高亚婷,王芳,马建红,马怡彤,刘畅..铜死亡在妇科恶性肿瘤中的研究进展[J].国际生殖健康/计划生育杂志,2024,43(1):74-78,5.基金项目
甘肃省科技厅重点研发计划(20YF3FA031) （20YF3FA031）
甘肃省卫生行业科研计划项目(GSWSKY2017-34) （GSWSKY2017-34）
