神经损伤与功能重建2024，Vol.19Issue(1)：33-36,62,5.DOI:10.16780/j.cnki.sjssgncj.20230624
神经血管功能障碍:脑淀粉样血管病潜在治疗靶点
Neurovascular Dysfunction:A Potential Therapeutic Target for Cerebral Amyloid Angiopathy
摘要
Abstract
Cerebral amyloid angiopathy(CAA)is a small cerebral vascular disease associated with aging,which is characterized by the excessive deposition of amyloid in cerebral vessels.Recent studies suggest that neurovascular unit(NVU)dysfunction may contribute to the development of CAA.This review will focus on the direct and indirect damage of NVU in CAA and the relationship between NVU and CAA from the aspects of clinical manifestations and imaging markers,it is hoped that by protecting the function of NVU,the occurrence and progress of CAA can be slowed down.关键词
脑淀粉样血管病/神经血管单元/淀粉样物质沉积Key words
cerebral amyloid angiopathy/neurovascular unit/amyloid deposition分类
医药卫生引用本文复制引用
叶嘉禾,叶晓东,李贤贤,黄珊珊,朱遂强..神经血管功能障碍:脑淀粉样血管病潜在治疗靶点[J].神经损伤与功能重建,2024,19(1):33-36,62,5.基金项目
2019湖北省技术创新专项(重大项目,脑淀粉样血管病早期诊断模型开发和干预,No.2019ACA132) （重大项目,脑淀粉样血管病早期诊断模型开发和干预,No.2019ACA132）
湖北省自然科学基金项目(表达突变TBP的小胶质细胞在17型小脑脊髓共济失调(SCA17)发病中的作用及机制研究,No.2020CFB805) （表达突变TBP的小胶质细胞在17型小脑脊髓共济失调(SCA17）
