神经血管功能障碍:脑淀粉样血管病潜在治疗靶点OACSTPCD
Neurovascular Dysfunction:A Potential Therapeutic Target for Cerebral Amyloid Angiopathy
脑淀粉样血管病(cerebral amyloid angiopathy,CAA)是一种与年龄相关的脑小血管病,主要特征为淀粉样物质在脑血管壁的沉积.近期研究认为,神经血管单元(neurovascular unit,NVU)功能障碍可能推动CAA的发生与发展.本文将主要围绕CAA中NVU的直接与间接损害及NVU功能障碍相关的临床表现、影像标志物等方面论述CAA与NVU功能障碍之间的关联,并探讨通过保护NVU的功能以减缓CAA的发生和进展的可能性.
Cerebral amyloid angiopathy(CAA)is a small cerebral vascular disease associated with aging,which is characterized by the excessive deposition of amyloid in cerebral vessels.Recent studies suggest that neurovascular unit(NVU)dysfunction may contribute to the development of CAA.This review will focus on the direct and indirect damage of NVU in CAA and the relationship between NVU and CAA from the aspects of clinical manifestations and imaging markers,it is hoped that by protecting the function of NVU,the occurrence and progress of CAA can be slowed down.
叶嘉禾;叶晓东;李贤贤;黄珊珊;朱遂强
华中科技大学同济医学院附属同济医院神经内科 武汉 430030
临床医学
脑淀粉样血管病神经血管单元淀粉样物质沉积
cerebral amyloid angiopathyneurovascular unitamyloid deposition
《神经损伤与功能重建》 2024 (001)
33-36,62 / 5
2019湖北省技术创新专项(重大项目,脑淀粉样血管病早期诊断模型开发和干预,No.2019ACA132);湖北省自然科学基金项目(表达突变TBP的小胶质细胞在17型小脑脊髓共济失调(SCA17)发病中的作用及机制研究,No.2020CFB805)
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