脊髓损伤动物模型研究进展OACSTPCD
Research Progress of Animal Models of Spinal Cord Injury
脊髓损伤致死率和致残率高、治疗耗费大且发病年龄呈现低龄化.现有脊髓损伤的临床治疗效果并不理想,给社会和家庭带来沉重负担.为进一步改进临床治疗手段,延长并提高脊髓损伤患者的寿命及生活质量,进一步明确脊髓损伤的病理生理机制必不可少.脊髓损伤的动物模型可较好地模拟脊髓损伤发生、发展过程,用以探讨脊髓损伤发病和治疗机制.目前已有多种不同的脊髓损伤模型用于脊髓发病机制和实验性治疗研究,本文对脊髓挫裂伤、脊髓压迫伤和脊髓横断伤等模型的应用和相关研究进展进行总结,为脊髓损伤模型的选择与制备提供参考.
Spinal cord injury(SCI)is characterized by high morbidity and mortality,high treatment cost,and young age of onset.The current clinical treatment effect is not ideal,causing a heavy burden to both society and family.In order to further improve the clinical treatment methods,and prolong and improve the life quality of patients with SCI,it is necessary to further clarify the pathophysiological mechanisms of SCI.The animal models of SCI can better simulate different stages of SCI,so as to facilitate the exploration of related pathophysiological mechanisms.Several different SCI models have been used to clarify the pathogenesis and experimental therapeutic treatment of SCI.This review summarizes the research progress and application of spinal cord contusion,spinal cord compression injury and spinal cord transection injury models,so as to offer a reference for a suitable choice and preparation of an SCI model.
刘彦君;赵炜疆
江南大学无锡医学院 江苏无锡 214122
临床医学
脊髓损伤动物模型
spinal cord injuryanimalmodel
《神经损伤与功能重建》 2024 (001)
37-40 / 4
国家自然科学基金面上项目(硫酸软骨素蛋白聚糖(CSPGs)结合肽联合激动型L1抗体治疗脊髓损伤实验研究,No.81471279;激动型神经细胞粘附分子L1治疗小鼠脊髓损伤实验研究,No.81171138);江苏省双创计划(基于关键靶蛋白筛选小分子化合物治疗阿尔茨海默病,No.JSSCRC2021533);江苏省高等学校大学生创新创业训练计划项目(神经调节蛋白2(NRG2)治疗小鼠脊髓损伤及相关机制研究,No.202110295144Y)
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