神经损伤与功能重建2024，Vol.19Issue(1)：37-40,4.DOI:10.16780/j.cnki.sjssgncj.20220325
脊髓损伤动物模型研究进展
Research Progress of Animal Models of Spinal Cord Injury
摘要
Abstract
Spinal cord injury(SCI)is characterized by high morbidity and mortality,high treatment cost,and young age of onset.The current clinical treatment effect is not ideal,causing a heavy burden to both society and family.In order to further improve the clinical treatment methods,and prolong and improve the life quality of patients with SCI,it is necessary to further clarify the pathophysiological mechanisms of SCI.The animal models of SCI can better simulate different stages of SCI,so as to facilitate the exploration of related pathophysiological mechanisms.Several different SCI models have been used to clarify the pathogenesis and experimental therapeutic treatment of SCI.This review summarizes the research progress and application of spinal cord contusion,spinal cord compression injury and spinal cord transection injury models,so as to offer a reference for a suitable choice and preparation of an SCI model.关键词
脊髓损伤/动物/模型Key words
spinal cord injury/animal/model分类
医药卫生引用本文复制引用
刘彦君,赵炜疆..脊髓损伤动物模型研究进展[J].神经损伤与功能重建,2024,19(1):37-40,4.基金项目
国家自然科学基金面上项目(硫酸软骨素蛋白聚糖(CSPGs)结合肽联合激动型L1抗体治疗脊髓损伤实验研究,No.81471279 （硫酸软骨素蛋白聚糖(CSPGs）
激动型神经细胞粘附分子L1治疗小鼠脊髓损伤实验研究,No.81171138) （）
江苏省双创计划(基于关键靶蛋白筛选小分子化合物治疗阿尔茨海默病,No.JSSCRC2021533) （基于关键靶蛋白筛选小分子化合物治疗阿尔茨海默病,No.JSSCRC2021533）
江苏省高等学校大学生创新创业训练计划项目(神经调节蛋白2(NRG2)治疗小鼠脊髓损伤及相关机制研究,No.202110295144Y) （神经调节蛋白2(NRG2）
