神经损伤与功能重建2024，Vol.19Issue(1)：45-50,6.DOI:10.16780/j.cnki.sjssgncj.20230415
纳米递送系统在脊髓损伤中的研究进展
Research Progress of Nano Delivery Systems in Spinal Cord Injury
摘要
Abstract
Spinal cord injury(SCI)is a severe neurological condition.The primary clinical interventions include emergency treatment,surgical procedures,drug therapy,and rehabilitation programs.However,Conventional drug therapy is difficult to cross the Blood-spinal cord barrier(BSCB)and cannot target damaged nerve tissue.In contrast,nano-drug delivery systems offer controlled release properties and can precisely target spinal cord tissue,thereby overcoming the limitations of traditional drug therapies.Through exquisite design,assembly and external modification,the nanomedical drug delivery system has outstanding therapeutic effects.This paper reviews the current research status of Nanoparticles for drug delivery in SCI.Furthermore,this article emphasizes the targeting strategies utilized in drug delivery systems for spinal cord injury,as well as the potential of nanoparticles and their respective characteristics and limitations.Finally,the efforts and obstacles to be overcome in the application of nanoparticle drug delivery technology in the field of clinical SCI repair are discussed.关键词
脊髓损伤/纳米粒子/靶向治疗/纳米递送Key words
spinal cord injury/nanoparticles/targeted therapy/nano delivery分类
医药卫生引用本文复制引用
叶启航,李艺,张云梦,叶军明..纳米递送系统在脊髓损伤中的研究进展[J].神经损伤与功能重建,2024,19(1):45-50,6.基金项目
国家科学自然基金(原位注射bFGF-ECM-HP温敏型水凝胶治疗脊髓损伤的作用和作用机制,No.81760230) （原位注射bFGF-ECM-HP温敏型水凝胶治疗脊髓损伤的作用和作用机制,No.81760230）
江西省科学自然基金(近红外光响应PDA-HP水凝胶改善线粒体功能的脊髓损伤光热治疗研究,No.20224BAB216047) （近红外光响应PDA-HP水凝胶改善线粒体功能的脊髓损伤光热治疗研究,No.20224BAB216047）
