纺织工程学报2023，Vol.1Issue(6)：1-14,14.
亲水粘附型壳聚糖织物的制备及其止血研究
Study of the Preparation and Homeostatic Properties of Hydrophilic Adhesive Chitosan Fabric
摘要
Abstract
To achieve rapid aggregation of red blood cells and platelets by absorbing and concentrating blood is particularly important for hemostasis.In order to improve the blood absorption capacity of chitosan fabric,carboxyethyl chitosan(CECS)fiber with different degree of carboxyethyl substitution was synthesized by the reaction between acrylic acid and chitosan fiber.Meanwhile,to improve the tissue adhesion of chitosan fab-ric,water-soluble protonated chitosan fiber(CS-HCl)was prepared by modifying chitosan fiber with HCl.Fur-thermore,polylactic acid(PLA)@CECS core-spun yarns were obtained by ring spinning of(PLA)filament as core layer and CECS fiber as sheath layer,then PLA@CECS@CS-HCl core-spun yarns with three-layer structure was obtained by covering CS-HCl fiber on PLA@CECS core-spun yarns.Finally,PLA@CECS@CS-HCl fabric(chitosan fabric)was prepared by knitting.Chitosan fabric has good hydrophilicity and also shows good vertical absorption of blood.Meanwhile,swollen chitosan fabrics also have excellent blood blocking property.Chitosan fabrics can tightly adhere to the surface of tissues.In the rabbit liver model and femoral ar-tery injury model,the hemostatic time and blood loss of the fabric(e.g.F-H-fabric)were significantly less than those of gauze,showing its excellent hemostatic properties.In addition,the fabric had good cytocompati-bility and blood compatibility.Chitosan fabric is a promising hemostatic material for fatal massive hemor-rhage in the future.关键词
壳聚糖/聚乳酸/纤维/纱线/织物/亲水性/粘附/止血Key words
chitosan/PLA/fiber/yarn/fabric/hydrophilicity/adhesiveness/hemostasis分类
轻工纺织引用本文复制引用
杨俊锋,周应山,万婷婷,杨凯聃,施金枝,陈瑞娜,王亚超,张思盈,胡雅新,董齐..亲水粘附型壳聚糖织物的制备及其止血研究[J].纺织工程学报,2023,1(6):1-14,14.基金项目
武汉市科技局应用基础前沿项目重大项目(2022023988065191) （2022023988065191）
武汉市科技局知识创新专项基础研究项目(2022020801010246). （2022020801010246）
