检验医学与临床2024，Vol.21Issue(2)：151-155,5.DOI:10.3969/j.issn.1672-9455.2024.02.002
长春市不同年龄段健康成人血清心肌酶谱水平观察
Observation of serum myocardial enzymes levels in healthy adults of different ages in Changchun
摘要
Abstract
Objective To establish the reference intervals of creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)and α-hydroxybutyrate dehydrogenase(α-HBDH)in Changchun adults by observing the levels of myocardial enzymes in healthy adults of different age groups based on the data of laboratory information management system.Methods The data of healthy adults in the laboratory information management system of the hospital from January 2019 to December 2020 were select-ed.K-S test was used to determine the normality of the data,log transformation was used to data with skewed distribution,box plot method was used to remove outliers,LMS method was used to fit continuous percentile curve,and Z test was used to compare the differences in gender and age.The upper and lower limits of the ref-erence intervals were calculated by nonparametric method,and the 90％confidence intervals were calculated by Bootstrap method.The applicability of the established reference intervals was verified.Results A total of 6831 healthy people aged 20-79 years were included.Except CK,CK-MB,LDH,α-HBDH data followed normal distribution,and 277 cases of data were excluded by box plot method.There were significant differences in CK and CK-MB levels between males and females(P＜0.05)in all age groups.There were significant differences in the levels of LDH and α-HBDH in males and CK,CK-MB/LDH and α-HBDH in females(P＜0.05).The reference intervals of CK obtained by nonparametric method were 53.0-273.0 U/L(20-79 years old)for men,41.0-162.7 U/L(20-49 years old)for women,and 42.0-187.8 U/L(50-79 years old)for women.CK-MB reference intervals were 8.5-24.1 U/L(20-79 years old)for men,7.3-22.5 U/L(20-69 years old)for women,and 7.5-24.9 U/L(70-79 years old)for women.The reference intervals of LDH in men and women were 133.0-244.0 U/L(20-59 years old)and 144.0-264.0 U/L(60-79 years old).The ref-erence interval of α-HBDH was 74.0-167.0 U/L(20-49 years old)in men and 79.0-183.0 U/L(50-79 years old)in women.The relative deviation between the LDH reference interval and the reference interval of a few studies was higher than the reference change value.All items of myocardial enzymes were verified by ap-plicability.Conclusion There are gender difference in CK and CK-MB of healthy adults in Changchun,and there are age differences in CK,CK-MB,LDH and α-HBDH of male and female.The levels of CK in healthy women,CK-MB,LDH,α-HBDH in male and female are gradually increased with age.关键词
间接法/肌酸激酶/肌酸激酶同工酶/乳酸脱氢酶/α-羟丁酸脱氢酶Key words
indirect method/creatine kinase/creatine kinase isoenzyme/lactic dehydrogenase/α-hydroxybutyrate dehydrogenase分类
医药卫生引用本文复制引用
何冰,王艺婷,李雪文,许建成..长春市不同年龄段健康成人血清心肌酶谱水平观察[J].检验医学与临床,2024,21(2):151-155,5.基金项目
吉林省科技发展计划项目(20230401095YY). （20230401095YY）
