检验医学与临床2024，Vol.21Issue(2)：156-160,165,6.DOI:10.3969/j.issn.1672-9455.2024.02.003
综合疗法治疗睑板腺功能障碍性干眼症疗效观察
Observation on the efficacy of comprehensive therapy in the treatment of dry eye syndrome with meibomian gland dysfunction
摘要
Abstract
Objective To observe and discuss the effect of comprehensive treatment on dry eye related mei-bomian gland dysfunction(DEMGD)in the elderly.Methods A total of 300 patients with DEMGD admitted to the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2021 to January 2023 were selected as the research objects,and they were divided into group A and group B by random number table method,with 150 cases in each group.Group A was given systemic comprehensive ther-apy,and group B was given conventional treatment.The auxiliary examination indexes of dry eye were ob-served before and after treatment in the two groups,and the levels of tumor necrosis factor-α(TNF-α),inter-leukin-1(IL-1)and intercellular adhesion molecule-1(ICAM-1)in conjunctival epithelial cells were detected.Results After treatment,the ocular symptoms and auxiliary examination results of the 2 groups were signifi-cantly improved compared with those before treatment,and those of group A were significantly better than those of group B,with statistically significant differences(P＜0.05).The levels of TNF-α,IL-1 and ICAM-1 in conjunctival epithelial cells in the 2 groups after treatment were significantly lower than before treatment,and those in group A were significantly lower than those in group B,with statistical significance(P＜0.05).The total effective rate of group A was significantly higher than that of group B,the difference was statistical-ly significant(P＜0.05).Conclusion Combined therapy is effective and safe in the treatment of DEMGD,which can significantly relieve the eye discomfort symptoms of patients,improve various auxiliary examination indicators,and reduce the levels of TNF-α,IL-1 and ICAM-1 in conjunctival epithelial cells,and is worthy of clinical promotion and application.关键词
睑板腺功能障碍性干眼症/综合疗法/中老年/炎症反应/疗效观察Key words
meibomian gland dysfunction dry eye/comprehensive treatment/the middle-aged and eld-erly/inflammation/curative effect observation分类
医药卫生引用本文复制引用
张静,刘韶瑞..综合疗法治疗睑板腺功能障碍性干眼症疗效观察[J].检验医学与临床,2024,21(2):156-160,165,6.基金项目
上海市虹口区卫生和计划生育委员会科研项目(虹卫1603-12). （虹卫1603-12）
