检验医学与临床2024，Vol.21Issue(2)：183-187,191,6.DOI:10.3969/j.issn.1672-9455.2024.02.009
腹膜透析相关性腹膜炎的致病菌及药敏试验分析
Analysis of pathogenic bacteria and drug sensitivity test in peritoneal dialysis-related peritonitis
摘要
Abstract
Objective To retrospectively analyze the characteristics of pathogenic bacteria spectrum and prognosis of peritoneal dialysis-associated peritonitis(PDAP)in the hospital,and to provide scientific basis for the prevention and treatment of peritonitis in the hospital.Methods The clinical data of 69 patients with PDAP admitted to the hospital from January 2017 to February 2023 were retrospectively selected,and the eti-ology,characteristics of pathogenic bacteria spectrum and prognosis were analyzed.Results A total of 43 pathogenic bacteria were cultured from 69 patients with PDAP,and the positive rate was 62.32％,including 23 cases of Gram-positive bacteria(53.49％),17 cases of Gram-negative bacteria(39.53％),and 3 cases of fungi(6.98％).The causes of 43 cases of pathogenic bacteria infection included:intestinal infection in 18 cases(41.86％),the operation of fluid exchange was not standard in 11 cases(25.58％),8 cases(18.60％)had re-spiratory tract infection,6 cases(13.95％)were unknown.Gram-positive bacteria were mainly Staphylococcus epidermidis(10 cases),and Gram-negative bacteria were mainly Escherichia coli(7 cases).Gram-positive bac-teria were sensitive to vancomycin,linezolid,tigecycline,teicoplanin and Moxifloxacin,but resistant to clinda-mycin(52.17％),erythromycin(56.52％),amoxicillin/clavulanic acid(60.87％)and penicillin G(78.26％).Gram-negative bacteria were sensitive Medopenem,Imipenem and colistin,but resistant to amoxicillin/clavu-lanic acid(47.06％),cefuroxime(47.06％),cefazolin(52.94％)and ampicillin(82.35％).Fungi were sensi-tive to fluconazole,voriconazole,amphotericin B and caspofungin.Among 69 patients with PDAP,53 cases were cured,14 cases withdrew and 2 cases died,with a cure rate of 76.81％.The dropout rate of patients with fungal PDAP was significantly higher than that of Gram-positive bacteria,Gram-negative bacteria and culture negative bacteria peritonitis.Conclusion The main causes of PDAP in PD patients in the hospital are irregular fluid exchange and intestinal infection.The main pathogenic bacteria associated with PDAP are Gram-positive bacteria,and the dropout rate of patients with fungal PDAP is high.关键词
腹膜透析相关性腹膜炎/腹膜透析/革兰阳性菌/革兰阴性菌/药敏试验/治愈率Key words
peritoneal dialysis related peritonitis/peritoneal dialysis/Gram-positive bacteria/Gram-negative bacteria/drug sensitivity test/cure rate分类
医药卫生引用本文复制引用
刘静,高玉伟,王兴华,胡秀红,崔红蕊,徐保振,杨洪娟,王涛..腹膜透析相关性腹膜炎的致病菌及药敏试验分析[J].检验医学与临床,2024,21(2):183-187,191,6.基金项目
河北省中医药管理局科学研究课题(2024027). （2024027）
