检验医学与临床2024，Vol.21Issue(2)：199-202,4.DOI:10.3969/j.issn.1672-9455.2024.02.013
人乳头瘤病毒感染情况、阴道微环境指标与宫颈病变的相关性分析
Correlation analysis of human papillomavirus infection,vaginal microenvironment index and cervical lesions
摘要
Abstract
Objective To investigate the correlation between human papillomavirus(HPV)infection,vagi-nal micro-environmental indicators and cervical lesions.Methods A total of 307 patients with cervical lesions admitted to the hospital from January 2022 to April 2023 were selected as the research objects.According to the results of liquid-based cytology(TCT)and pathological examination,they were divided into low grade in-traepithelial neoplasia(LSIL)group(169 cases),high grade intraepithelial neoplasia(HSIL)group(97 ca-ses)and cervical cancer(SCC)group(41 cases).In addition,200 healthy subjects with normal TCT results and no cervical lesions were selected as the control group.All subjects were tested for HPV and vaginal micro-environment.Spearman correlation was used to analyze the correlation between age and the severity of cervical cancer.Results The severity of cervical lesions was positively correlated with age(r=0.306,P＜0.05).HPV infection rates were higher in 16,52,58 and 53 types.The multiple infection rates of HPV in LSIL,HSIL and SCC groups were higher than those in the control group,and those in HSIL and SCC groups were higher than those in LSIL group,the differences were statistically significant(P＜0.05).There was no significant differ-ence in HPV multiple infection rate between SCC group and HSIL group(P＞0.05).The proportion of Ph value(pH),hydrogen peroxide(H2O2)and leukocyte esterase(LE)were SCC group＞HSIL group＞LSIL group＞control group,and the 3 groups compared with control group,the differences were statistically signifi-cant(P＜0.05).The proportion of abnormal vaginal cleanliness was SCC group＞HSIL group＞LSIL group＞control group.There was no significant difference in the proportion of abnormal vaginal cleanliness between the LSIL group and the control group(P＞0.05).The proportion of abnormal vaginal cleanliness in the HSIL group,SCC group and the control group were significantly different(P＜0.05).Multivariate Logis-tic regression analysis showed that vaginal pH＞4.5,LE positive,Ⅲ °-Ⅳ° cleanliness increased the risk of cervical lesions,H2O2 positive had inhibitory effect on the occurrence of cervical lesions.Conclusion HPV in-fection and abnormal changes of vaginal micro-environmental indicators are related to the occurrence and de-velopment of cervical diseases,which can provide reference for clinical prevention and treatment in cervical le-sions.关键词
人乳头瘤病毒/阴道微环境/宫颈病变/感染情况/低级别上皮内瘤变/高级别上皮内瘤变/宫颈癌Key words
human papillomavirus/the vaginal environment/cervical lesions/infection status/low grade intraepithelial neoplasia/high grade intraepithelial neoplasia/cervical cancer分类
医药卫生引用本文复制引用
张林光,刘亚丽,董涛..人乳头瘤病毒感染情况、阴道微环境指标与宫颈病变的相关性分析[J].检验医学与临床,2024,21(2):199-202,4.基金项目
河北省秦皇岛市科学技术研究与发展计划(202301A232). （202301A232）
