摘要
Abstract
Objective To investigate the relationship between hepatic steatosis index(HSI)and type 2 dia-betes mellitus(T2DM)combined with coronary heart disease(CHD).Methods A total of 248 T2DM pa-tients who underwent coronary angiography(CAG)in the department of Cardiology of,Wuhan Third Hospi-tal from January 2017 to December 2022 were selected as the research subjects.The gender,age,height,weight,body mass index(BMI)and biochemical examination indexes of all subjects were collected,and HSI was calculated according to the formula.According to CAG results,all subjects were divided into CHD group(82 cases)and non-CHD group(166 cases).The binary Logistic regression was used to analyze the risk fac-tors of CHD in T2DM patients,and receiver operating characteristic(ROC)curve was used to evaluate the predictive value of HSI in CHD in T2DM patients.Results There were significant differences in BMI,total cholesterol,low-density lipoprotein cholesterol,plasma albumin(ALB),globulin(AGB),uric acid,glycosylat-ed hemoglobin and HSI between the CHD group and the non-CHD group(P＜0.05).The binary Logistic re-gression analysis showed that ALB＜40.90 g/L,AGB＞25.65 g/L and HSI＞39.94 were independent risk fac-tors for CHD in T2DM patients(P＜0.05).ROC curve analysis showed that the area under the curve of HSI for predicting CHD in T2DM patients was 0.556,the Youden index was 0.117,the sensitivity was 38.8％,and the specificity was 72.9％.Conclusion High level of HSI is a risk factor for CHD in patients with T2DM,and HSI has a certain predictive value for CHD in patients with T2DM.关键词
肝脂肪变性指数/冠心病/2型糖尿病/胰岛素抵抗/诊断效能Key words
hepatic steatosis index/coronary heart disease/type 2 diabetes mellitus/insulin resist-ance/diagnostic efficacy分类
医药卫生
