检验医学与临床2024，Vol.21Issue(2)：221-224,4.DOI:10.3969/j.issn.1672-9455.2024.02.018
老年ACI患者血清CYR61、氧化应激分子水平及其对ACI患者90 d预后的预测价值
Serum levels of CYR61 and oxidative stress molecules in elderly patients with ACI and their predictive value for 90 d prognosis in patients with ACI
孙国才 1赵旭锐 1权泽威 1朱娇 2王彩霞 1秦燕1
作者信息
- 1. 兵器工业五二一医院老年病科,陕西西安 710065
- 2. 兵器工业五二一医院肿瘤血液病科,陕西西安 710065
- 折叠
摘要
Abstract
Objective To investigate the levels of serum cysteine-rich protein 61(CYR61),malondialdehyde(MDA),superoxide dismutase(SOD)and myelin basic protein(MBP)in elderly patients with acute cerebral infarction(ACI)and their predictive value for 90-day prognosis.Methods A total of 211 ACI patients admit-ted to the hospital from June 2019 to January 2022 were selected as the ACI group,and 200 healthy physical examination subjects during the same period were selected as the control group.The serum CYR61,MDA,SOD and MBP levels of the two groups were detected.According to the modified Rankin scale(mRS)score,ACI patients who were followed up for 90 d were divided into good prognosis group(mRS score＜2)and poor prognosis group(mRS score＞2).The clinical data of the good prognosis group and the poor prognosis group were compared,and multivariate Logistic regression analysis was performed.The receiver operating character-istic(ROC)curve was used to evaluate the predictive value of serum CYR61 level for the 90 d prognosis of ACI patients.Results The levels of CYR61,MDA and MBP in ACI group were significantly higher than those in control group(P＜0.05),and the level of SOD was significantly lower than that in control group(P＜0.05).Pearson correlation analysis showed that serum CYR61 level in ACI patients was positively correlated with MDA and MBP levels,and negatively correlated with SOD level(r=0.447,0.605,-0.551,P＜0.05).There were significant differences in age,National Institutes of Health Stroke Scale(NIHSS)score on the day of admission,time from onset to treatment and levels of CYR61,MDA,MBP and SOD between the good prog-nosis group and the poor prognosis group(P＜0.05).Multivariate Logistic regression analysis showed that NIHSS score and serum CYR61 level on admission were the influencing factors of poor prognosis of ACI pa-tients at 90 d(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum CYR61 for predicting poor prognosis of ACI patients at 90 d was 0.798,and the sensitivity and specificity were 0.857 and 0.652 respectively.The AUC of NIHSS score on admission to predict poor prognosis at 90 d was 0.811,and the sensitivity and specificity were 0.857 and 0.783 respectively.Conclusion The serum CYR61 level is increased in ACI patients,which may be involved in the regulation of oxidative stress.The CYR61 level is a in-fluencing factor for poor prognosis in patients with ACI,and has a certain early predictive value.关键词
急性脑梗死/富半胱氨酸蛋白61/氧化应激分子/预后/老年Key words
acute cerebral infarction/cysteine-rich protein 61/oxidative stress molecule/prognosis/the elderly分类
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孙国才,赵旭锐,权泽威,朱娇,王彩霞,秦燕..老年ACI患者血清CYR61、氧化应激分子水平及其对ACI患者90 d预后的预测价值[J].检验医学与临床,2024,21(2):221-224,4.
