摘要
Abstract
Objective To investigate the expression of Galectin-9 and Cadherin-11 in pancreatic cancer and their relationship with clinicopathological features and prognosis.Methods A total of 107 cases of pancreatic cancer tissues and adjacent tissues were collected from the Affiliated Hospital of Shangluo Vocational and Technical College from January 2019 to December 2021.The expression of Galectin-9 and Cadherin-11 was de-tected by immunohistochemistry.The relationship between the expression of Galectin-9 and Cadherin-11 in cancer tissues and clinicopathological features was analyzed.Kaplan-Meier survival curve analysis was used to explore the relationship between the expression of Galectin-9 and Cadherin-11 and prognosis.Results The to-tal positive expression rate of Galectin-9 protein in pancreatic cancer tissues was lower than that in adjacent tissues,and the difference was statistically significant(P＜0.05).The total positive expression rate of Galec-tin-9 protein was significantly different in tumor tissues with different tumor diameter,tumor stage and lymph node metastasis(P＜0.05).The total positive expression rate of Cadherin-11 protein in pancreatic cancer tis-sues was lower than that in adjacent tissues,and the difference was statistically significant(P＜0.05).The to-tal positive expression rate of Cadherin-11 protein in different tumor maximum diameter,differentiation de-gree,tumor stage,lymph node metastasis,vascular invasion and nerve invasion was statistically significant(P＜0.05).Followed up to December 2021,71 of 107 patients died and 36 survived.The overall survival time was 3-52 months,with an average of(20.46±10.60)months.Kaplan-Meier survival curve analysis showed that the cumulative survival rate of Galectin-9 positive patients was 34.0％,which was not significantly dif-ferent from 33.3％of Galectin-9 negative patients(Log Rank x2=0.418,P=0.518).The cumulative survival rate of Cadherin-11 positive patients was 43.9％,which was significantly higher than 15.6％of Cadherin-11 negative patients,and the difference was statistically significant(Log Rank x2=10.796,P＜0.001).Conclu-sion The down-regulation of Galectin-9 and Cadherin-11 protein expression may be involved in the occur-rence and development of pancreatic cancer.The negative expression of Cadherin-11 protein may have a certain predictive value for the poor prognosis of pancreatic cancer.关键词
胰腺癌/半乳糖凝集素-9/钙黏蛋白-11/临床病理特征/预后Key words
pancreatic cancer/Galectin-9/Cadherin-11/clinical pathology feature/prognosis分类
医药卫生
