摘要
Abstract
Objective To investigate the effect of adding and reducing Chaihu Wenjing decoction in the treatment of insomnia patients with liver-stagnation Yin deficiency and its influence on neurotransmitter and emotion.Methods A total of 94 cases of insomnia with liver-stagnation and Yin deficiency treated in our hos-pital from May 2021 to May 2022 were selected as research objects,and were divided into conventional group and experimental group by random number table method,with 47 cases in each group.The conventional group was treated with Bailemian capsule,and the experimental group was treated with Bailemian capsule combined with Chaihu Wenjing decoction.The clinical efficacy,related scores before and after treatment[Hamilton De-pression Scale(HAMD),Pittsburgh Sleep Quality Index(PSQI),Hamilton Anxiety Scale(HAMA)],TCM syndrome score,serum neurotransmitters[5-hydroxytryptamine(5-HT),neuropeptide(NPY),norepineph-rine(NE),substance P(SP)]levels,sex hormones[estradiol(E2),luteinizing hormone(LH),follicle stimu-lating hormone(FSH)]levels.Results The total effective rate of the experimental group was 97.87％,which was higher than 82.98％of the conventional group,and the difference was statistically significant(P＜0.05).After treatment,the PSQI,HAMD and HAMA scores of the two groups were significantly lower than those before treatment,and the experimental group was significantly lower than the conventional group,the differ-ences were statistically significant(P＜0.05).After treatment,the scores of irritability,difficulty falling a-sleep,easy to wake up from multiple dreams and emotional depression in the experimental group were signifi-cantly lower than those in the conventional group,and the differences were statistically significant(P＜0.05).After treatment,the levels of NPY and 5-HT in the experimental group were higher than those in the conventional group,and the levels of NE and SP were lower than those in the conventional group,with statisti-cally significant differences(P＜0.05).After treatment,the levels of FSH and LH in the experimental group were significantly lower than those in the conventional group,and the level of E2 was significantly higher than that in the conventional group,and the differences were statistically significant(P＜0.05).Conclusion Adding and reducing Chaihu Wenjing decoction can improve the curative effect in the treatment of insomnia with liver de-pression and Yin deficiency and blood stasis,improve the clinical symptoms,neurotransmitter and sex hor-mone levels,reduce their negative emotions and help patients recover.关键词
加减柴胡温经汤/肝郁阴虚夹瘀型失眠/神经递质/情绪/临床症状Key words
adding and reducing Chaihu Wenjing decoction/insomnia with liver depression and Yin defi-ciency and blood stasis/neurotransmitter/mood/clinical symptoms分类
医药卫生
