临床与实验病理学杂志2024，Vol.40Issue(1)：24-28,5.DOI:10.13315/j.cnki.cjcep.2024.01.007
伴有MYC基因重排和11q异常的高级别B细胞淋巴瘤的临床病理学分析
High grade B cell lymphoma with concurrent MYC rearrangement and 11q aberrations:a clinicopathological analysis
摘要
Abstract
Purpose To investigate the clinicopathological features,molecular genetics and prognosis of high grade B cell lymphoma with concurrent MYC rearrangement and 11q aberra-tions(HGBCL-MYC-11q).MethodsThree cases of HGBCL-MYC-11q were reviewed and analyzed using hematoxylin-eosin staining,immunohistochemistry,EBER in situ hybridization and fluorescence in situ hybridization.Clinical data were collected with follow-up.Results All three patients were male,age was 10,61,and 74 years,respectively.All patients had Ann Arbor stage Ⅳ disease.All three cases were biopsies occurring in the nasopharynx,upper pharynx and ileocecus,respectively.Three cases were morphologically similar to diffuse infiltrative growth of tumor cells,moderate or moderately large cells,round to slightly irregular nuclei and easily visible mitotic figures.Focal necrosis was noted in one case.One case exhibited the distinct"starry sky"pattern.All cases expressed CD20,BCL6 and MUM1 and high Ki67 index,two cases expressed CD10 and two cases ex-pressed BCL2.CD3,CD30 and TDT were all negative.EBER in situ hybridization was all negative.FISH analyses using C-MYC break-apart probes were all positive and all cases had 11q aberrations.One case only had the 11q23.3 amplification;and one case only had the 11q24.3 loss.After a follow-up for 1-18 months,one patient died and two patients survived with disease.ConclusionHGBCL-MYC-11q is rare,morphologically similar to BL/HGBCL,with MYC rearrangement and 11q abnormali-ties.We should enhance awareness of the disease and improve more accurate diagnosis and differential diagnosis of the disease.关键词
高级别B细胞淋巴瘤/MYC基因重排/11q异常Key words
high grade B cell lymphoma/MYC rearrangement/11q aberrations分类
医药卫生引用本文复制引用
路素素,李文才,王冠男,赵武干,张丹丹,张延平,黄思夏,刘恩杰,王伟伟,张岚..伴有MYC基因重排和11q异常的高级别B细胞淋巴瘤的临床病理学分析[J].临床与实验病理学杂志,2024,40(1):24-28,5.基金项目
国家自然科学基金面上项目(82170184) （82170184）
