临床与实验病理学杂志2024，Vol.40Issue(1)：60-65,6.DOI:10.13315/j.cnki.cjcep.2024.01.014
MYC蛋白高表达弥漫大B细胞淋巴瘤45例分子特征分析
Molecular characteristics of diffuse large B-cell lymphoma with high expression of MYC:analysis of 45 cases
摘要
Abstract
Purpose To explore the molecular features of diffuse large B-cell lymphoma(DLBCL)with high expression of MYC.Methods The clinical data of 45 cases of DLBCL were collected.Immunohistochemical EnVision method was used to classify the patients into the group with high expression of MYC and the group with low expression of MYC.All samples were subjected to DNA targeted sequencing and molecular typing was performed using the LymphGen online tool.Cellular origin was determined by using the Lymph2Cx method.The correlation be-tween MYC overexpression and clinicopathological parameters was analyzed by the x2 test and Fisher precise test.Survival curves were drawn and survival-related factors were analyzed u-sing Cox univariate and multivariate regression.ResultsCases were classified into DLBCL with high expression of MYC(n=17)and DLBCL with low expression of MYC(n=28).Com-pared to the group with low expression of MYC,the group with high expression of MYC had more PIM1,MYD88,CD79B,CD58 and PRDM1 mutations(76.5％vs 28.6％,70.6％vs 32.1％,58.8％vs28.6％,29.4％vs3.6％,29.4％vs 3.6％,P＜0.05),MCD were more frequently found(58.8％vs 10.7％,P=0.001),GCB were rarely found(17.6％vs 50.0％,P=0.030).Overall survival was significantly shorter in DLBCL with high expression of MYC(P＜0.05).Cox multi-factorial analysis showed that age was an independent prognostic factor for DLBCL(P＜0.05).Conclusion Patients with high expression of MYC were frequently characterized as MCD and ABC,and PIM1,MYD88,CD79B,CD58 and PRDM1 muta-tions were common.Patients with high expression of MYC had a poorer prognosis.关键词
弥漫大B细胞淋巴瘤/MYC/分子分型/细胞起源/免疫组织化学Key words
diffuse large B-cell lymphoma/MYC/molecular typing/cellular origin/immunohistochemistry分类
医药卫生引用本文复制引用
刘念,马东慎,顾滢,骆丹,范美婷,王玉波,向臣希,刘慧..MYC蛋白高表达弥漫大B细胞淋巴瘤45例分子特征分析[J].临床与实验病理学杂志,2024,40(1):60-65,6.基金项目
徐州市推动科技创新项目重点研发计划(KC21207) （KC21207）
