环境与职业医学2024，Vol.41Issue(1)：103-109,7.DOI:10.11836/JEOM23232
空气污染对花粉症的影响及其机制研究进展
Research progress on effects of air pollution on pollinosis and its mechanisms
摘要
Abstract
Pollinosis is one of the common allergic diseases,and its morbidity continues to increase.Studies have demonstrated that air pollution is a key environmental factor that leads to the in-creased prevalence of pollinosis.Air pollutants and pollen allergens exert synergistic effects in stimulating allergic responses in susceptible individuals.In this article,we analyzed the relationship between air pollution and pollinosis based on the latest studies,and elaborated potential mech-anisms on how air pollution increases the incidence of pollinosis and aggravates allergic reac-tions.Air pollutants can increase both pollen production and the levels of allergenic proteins,and enhance allergenicity of pollen allergens through structural alterations or chemical modifica-tions.The potential mechanisms of air pollutants exacerbating pollen allergies are as follows:Air pollutants may disrupt the barrier function of the respiratory epithelium and facilitate the pene-tration of pollen allergens into deeper tissues.Additionally,they may accelerate the process of the release of pollen allergy-related cytokines,promoting T helper 2(Th2)cell differentiation and exacerbating inflammatory responses in the airways.Given the limitations of existing re-search,future prospective studies are needed to explore the effects of mixed pollutants and dif-ferent types of pollutants on pollen,and the response mechanisms of allergy-related cells and cytokines to different pollutant categories.The findings would provide a comprehensive under-standing of the impacts of air pollution on pollen allergies and scientific evidence for effective protection of the heath of pollinosis patients.关键词
空气污染/花粉症/过敏/致敏蛋白/致敏性/机制Key words
air pollution/pollinosis/allergy/allergenic protein/allergenicity/mechanism分类
医药卫生引用本文复制引用
卢琪,吴越,张启航,邓珊..空气污染对花粉症的影响及其机制研究进展[J].环境与职业医学,2024,41(1):103-109,7.基金项目
辽宁省自然科学基金计划项目(2023-MS-256) This study was funded. （2023-MS-256）
