环境与职业医学2024，Vol.41Issue(1)：110-117,8.DOI:10.11836/JEOM23250
食源性抗氧化剂缓解内分泌干扰物生殖毒性的研究进展
Research progress on food-derived antioxidants for alleviating toxicity of endocrine disrupting chemicals
摘要
Abstract
Endocrine disrupting chemicals(EDCs)are a class of chemical substances widely present in daily-life environment,and can enter human body through various pathways,posing a threat to reproductive development and health.Oxidative stress(OS)is one of the most important funda-mental mechanisms underlying the reproductive toxicity of EDCs.Numerous studies have found that exposure to EDCs can increase the levels of reactive oxygen species(ROS)in human repro-ductive system and reduce the activity and quantity of multiple enzymatic antioxidants,leading to oxidative stress and inducing damage to the reproductive system at various levels such as DNA and cells.Many research results have shown that supplementing food-derived non-enzymatic antioxidants can reduce ROS levels and increase the activity of enzymatic antioxidants,thereby reduce OS levels,and further repair EDCs-induced reproductive damage.In addition,many food-derived antioxidants are important elements involved in reproductive physiological activities and have protective effects on reproductive health.This paper summarized the reproductive toxicity of EDCs,including damage to reproductive cells,interference with hormone action,and influence on reproductive-related epigenetic regulation,elaborated the relationship between OS and re-productive toxicity of EDCs,and further summarized the alleviating effects and related mecha-nisms of food-derived antioxidants such as vitamins,trace elements,and plant polyphenols and pigments against reproductive toxicity of EDCs,aiming to provide a theoretical and scientific basis for prevention and treatment against reproductive toxicity of EDCs.关键词
内分泌干扰物/食源性抗氧化剂/生殖毒性/氧化应激/表观遗传调控Key words
endocrine disrupting chemical/food-derived antioxidant/reproductive toxicity/oxida-tive stress/epigenetic regulation分类
医药卫生引用本文复制引用
陈佳娴,苗茂华,王子亮..食源性抗氧化剂缓解内分泌干扰物生殖毒性的研究进展[J].环境与职业医学,2024,41(1):110-117,8.基金项目
国家自然科学基金项目(81903346) （81903346）
上海市自然科学基金项目(23ZR1457100) （23ZR1457100）
上海市生物医药技术研究院省部级重点实验室创新能力专项资助项目(RC2023-03) This study was funded. （RC2023-03）
