皮肤性病诊疗学杂志2024，Vol.31Issue(1)：9-14,6.DOI:10.3969/j.issn.1674-8468.2024.01.002
窄谱强脉冲光联合他克莫司软膏治疗Ⅰ型玫瑰痤疮的疗效及安全性
Efficacy and safety of DPL500 combined with tacrolimus ointment in the treatment of typeⅠ rosacea
苏淡彬 1李其林 2任英云 1刘雅慧 1李嘉萍1
作者信息
- 1. 前海人寿广州总医院,广东 广州 511300
- 2. 前海人寿广州总医院,广东 广州 511300||暨南大学附属广州红十字会医院,广东 广州 510220
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of DPL500 combined with tacrolimus ointment in the treatment of type Ⅰ rosacea.Methods A total of 80 patients with type Ⅰ rosa-cea were enrolled at the Foresea Life Insurance Guangzhou General Hospital from October 2020 to September 2022,and randomly divided into the observation and control groups,40 cases per group.The observation group was treated with DPL500 once a month and 0.1％tacrolimus oint-ment twice-daily for 3 months,while the control group was treated with 0.1％tacrolimus ointment alone.The efficacy and safety were compared between the two groups.Results Following the treatment,the total effective rate was higher in the observation group than in the controls(97.50％vs.80.00％,x2=4.51,P＜0.05).More rapid improvements in skin flushing,telan-giectasia,erythema and skin sensitivity were observed in the observation group compared to the controls(P＜0.05).Although the baseline subjective and objective scores did not differ signifi-cantly between the two groups(P＞0.05),both subjective and objective scores in the observation group were significantly lower than that in the controls after 30-,60-and 90-day treatment(P＜0.05).However,adverse reactions were comparable between the two groups(x2=0.18,P=0.672).Conclusions DPL500 combined with tacrolimus ointment is effective and safe in the treatment of type Ⅰ rosacea.It can quickly improve the facial symptoms.关键词
窄谱强脉冲光/他克莫司软膏/Ⅰ型玫瑰痤疮/临床疗效/安全性Key words
DPL500/tacrolimus ointment/type Ⅰ rosacea/clinical efficacy/safety引用本文复制引用
苏淡彬,李其林,任英云,刘雅慧,李嘉萍..窄谱强脉冲光联合他克莫司软膏治疗Ⅰ型玫瑰痤疮的疗效及安全性[J].皮肤性病诊疗学杂志,2024,31(1):9-14,6.
