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阿那白滞素在炎症性皮肤病中的临床应用OA

Application of anakinra in inflammatory dermatoses

中文摘要英文摘要

白细胞介素-1(IL-1)是一种重要的细胞因子,参与许多炎症性疾病的发病.IL-1抑制剂成为治疗这类疾病的有效方法.阿那白滞素(anakinra)是最早上市且应用最多的IL-1抑制剂,在一些炎症性皮肤病中显示出良好的疗效.本文主要就阿那白滞素在成人Still病、Schnitzler综合征、化脓性汗腺炎、脓疱型银屑病、白塞病、坏疽性脓皮病中的临床应用进行综述.

Interleukin 1(IL-1)is an important cytokine,which is involved in the development of many inflammatory diseases.IL-1 inhibitors have become an effective approach in the treatment of these diseases.Anakinra is the first and the most widely used IL-1 inhibitor on the market.Studies have shown satisfactory efficacy in the treatment of some inflammatory dermatoses.This re-view mainly summarizes applications of anakinra in adult-onset Still's disease,Schnitzler syn-drome,hidradenitis suppurativa,pustular psoriasis,Bechet disease and pyoderma gangrenosum.

游晓媚;古甘霖;江燕云;王亮春

中山大学孙逸仙纪念医院,广东 广州 510120中山大学孙逸仙纪念医院,广东 广州 510120中山大学孙逸仙纪念医院,广东 广州 510120中山大学孙逸仙纪念医院,广东 广州 510120

IL-1IL-1抑制剂阿那白滞素炎症性皮肤病

IL-1IL-1 inhibitorsanakinrainflammatory skin diseases

《皮肤性病诊疗学杂志》 2024 (1)

41-47,7

10.3969/j.issn.1674-8468.2024.01.008

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