皮肤性病诊疗学杂志2024，Vol.31Issue(1)：48-55,8.DOI:10.3969/j.issn.1674-8468.2024.01.009
角质形成细胞与2型炎症互作在特应性皮炎发病机制中的作用
The role of interaction between keratinocytes and type 2 inflammation in the pathogenesis of atopic dermatitis
摘要
Abstract
Patients with atopic dermatitis(AD)have skin barrier dysfunction,which is closely related to keratinocyte(KC)abnormalities.Upon stimulation by external factors,KCs release a large number of inflammatory mediators,thereby activating type 2 inflammation,which,in turn,exacerbates skin barrier dysfunction.Thus,the interaction between KCs and type 2 inflammation is a key factor in the pathogenesis of AD,and exacerbation of inflammation and pruritus.At pres-ent,the innovative medications,such as biologies and small molecule drugs,have been shown an-ti-inflammatory effects in AD.Studies also demonstrate their role in skin barrier repair.Therefore,research on the interaction between KCs and type 2 inflammation will help understand the patho-genesis of AD and provide evidence to optimize treatment strategies for AD.关键词
特应性皮炎/角质形成细胞/2型炎症/生物制剂/小分子药Key words
atopic dermatitis/keratinocyte/type 2 inflammation/biologics/small molecule drugs引用本文复制引用
张睿文,黄小宝,王芳..角质形成细胞与2型炎症互作在特应性皮炎发病机制中的作用[J].皮肤性病诊疗学杂志,2024,31(1):48-55,8.基金项目
国家自然科学基金(82273511) （82273511）
国家自然科学基金委员会中德科学中心中德合作交流项目(M-0747) （M-0747）
广东省自然科学基金(2022B1515020067) （2022B1515020067）
中山大学创新人才培育计划项目(22ykqb03) （22ykqb03）
