病毒感染与宿主抗感染免疫之间"博弈"——凋亡、坏死和焦亡分子机制OA北大核心CSTPCD

Cell death is an important component of host antiviral immunity response,viral infection can cause different forms of host cell death,including the lytic and non-lytic cell death mode.These types of cell death not only eliminate virus-infected cells,but also further promote the host's innate and adaptive immune processes through release of inflammatory factors.On the contrary,viruses have developed different circumvention mechanisms to inhibit cell death and promote itself infection.This review summarized the research progress in the regulation mechanism of virus-host infection and anti-infection immunity struggle-apoptosis,necroptosis and pyroptosis,aiming to provide references for further understanding the viral molecules pathogenesis and developing a new antiviral strategy.