畜牧兽医学报2024，Vol.55Issue(1)：71-78,8.DOI:10.11843/j.issn.0366-6964.2024.01.008
肺泡上皮细胞分泌的外泌体调控巨噬细胞极化在急性肺损伤中的作用
Role of Exosomes Secreted by Alveolar Epithelial Cells in Regulating Macrophage Polarization in Acute Lung Injury
摘要
Abstract
As messengers in the intercellular microenvironment,exosomes can mediate the transmission of signals between cells.Alveolar epithelial cells can regulate the body's innate immune response in the form of exosomes.Under specific stimulation conditions,exosomes derived from alveolar epithelial cells target and regulate the gene expression pathway by delivering different effector active substances,and participate in the regulation of macrophage polarization,thereby controlling the pulmonary inflammatory response.This article reviews the latest research progress of alveolar epithelial cell-derived exosomes in regulating acute lung injury(ALI)by targeting macrophage polarization,provide reference for related research.关键词
脓毒症/急性肺损伤/肺泡上皮细胞/巨噬细胞/外泌体Key words
sepsis/acute lung injury/alveolar epithelial cells/alveolar macrophages/exosomes分类
农业科技引用本文复制引用
王鑫鑫,林树梅,赵冬冬,王学生..肺泡上皮细胞分泌的外泌体调控巨噬细胞极化在急性肺损伤中的作用[J].畜牧兽医学报,2024,55(1):71-78,8.基金项目
国家自然科学基金项目(32172813) （32172813）
