畜牧与兽医2024，Vol.56Issue(2)：136-141,6.
羧化不全骨钙素与雄性动物生殖关系研究进展
Progressin research on the relationship between osteocalcin and male animal reproduction
摘要
Abstract
Osteocalcin(OCN)is a kind of polypeptide hormone secreted by osteoblasts,with carboxylated and incomplete carboxylated structures.OCN has been proved to exert a variety of endocrine functions through its metabolically-active form—hypocarboxylated OCN(uOCN),such as in glucose and energy metabolism,reproductive ability of male animals and their brain growth and development.Studies have shown that OCN can promote the production and secretion of testosterone in testicular interstitial cells of male animals through insulin,the vitamin D-mediated pathway and hypothalamic-pituitary-gonadal axis,thus improving the reproductive ability of the animals.Therefore,it is particularly important to further study the relationship between OCN and male animal reproduction,which may not only help improve the reproductive ability of male animals,but also avoid the harm to the animals caused by drug abuse.This article reviews related studies,focu-sing on the production of OCN,the structure of OCN,the function of OCN conducive to the production of testosterone in testicular interstitial cells and related mechanisms,aiming to offer reference for research on and practice in human and animal reproductive health.关键词
骨钙素/成骨细胞/生殖/睾酮Key words
osteocalcin/osteoblast/procreation/testosterone分类
农业科技引用本文复制引用
张新科,朱雪丹,陈云,刘松柏,王明明,李思琪,张守全..羧化不全骨钙素与雄性动物生殖关系研究进展[J].畜牧与兽医,2024,56(2):136-141,6.基金项目
广东省现代农业产业技术体系生猪创新团队项目(2022KJ126) （2022KJ126）
广州市科技局项目(202103000068) （202103000068）
广东省基础与应用基础研究基金项目(2023A1515010232) （2023A1515010232）
2021年度韶关市科技计划项目(210728094530484) （210728094530484）
