中国临床药理学与治疗学2024，Vol.29Issue(1)：68-75,8.DOI:10.12092/j.issn.1009-2501.2024.01.007
高血压药物基因多态性分析对安徽皖南地区高血压患者个体化治疗的参考价值
Clinical value of genetic polymorphism analysis of hypertension drugs for individualized treatment of hypertension patients in the southern Anhui region
摘要
Abstract
AIM:To analyze the distribution fre-quency of gene polymorphisms of β receptor block-ers,angiotensin receptor antagonists,angiotensin converting enzyme inhibitors,calcium antagonists,and diuretics in hypertensive patients from south-ern Anhui province,and provide a theoretical basis for gene detection of hypertension drugs and per-sonalized medication.METHODS:Drug gene test-ing information from 839 hospitalized patients with hypertension at Yijishan Hospital of Wannan Medi-cal College from July 2021 to April 2023 were col-lected,and the distribution frequency of each gene locus were analyzed.RESULTS:The genotype frequencies of ACE(I/D)I/I,I/D,and D/D were 42.1％,46.0％,and 11.9％,respectively,the geno-type frequencies of ADRB1(1165G＞C)G/G,G/C,and C/C were 8.3％,40.0％,and 51.6％,respectively.The genotype frequencies of AGTR1(1166A＞C)A/A,A/C,and C/C were 90.2％,9.8％,and 0.0％.The gen-otype frequencies of CYP2C9*3(1075A＞C)*1/*1,*1/*3,and*3/*3 were 91.3％,8.7％,and 0.0％,re-spectively;the genotype frequencies of CYP2D6*10(100C＞T)*1/*1,*1/*10,and*10/*10 were 25.0％,36.6％,and 38.4％,respectively.The geno-type frequencies of CYP3A5*3(6986A＞G)*1/*1,*1/*3,and*3/*3 were 7.0％,39.0％,and 54.0％,re-spectively.The frequencies of NPPA(2238T＞C)T/T,T/C,and C/C genotypes were 97.9％,2.1％,and 0.0％,respectively.In addition,there was a signifi-cant difference in the genotype distribution fre-quency of multiple drug related gene loci in south-ern Anhui compared to other regions in China(P＜0.05).CONCLUSION:The genotype distribution fre-quency of hypertensive drug related gene loci had certain bias in southern Anhui,and were significant different from other regions in China,indicating that conducting genetic polymorphism testing of hypertensive drugs had certain guiding significance for the individualized application of hypertensive drugs in southern Anhui.关键词
高血压药物/药物代谢酶基因/药物作用靶点基因/基因多态性/个体化用药Key words
hypertensive drugs/drug metabolism enzyme genes/target genes of drug/genetic poly-morphism/individualized medication分类
临床医学引用本文复制引用
万淑君,张梦莹,陈其雷,钟民,朱小龙,张莺莺,吕坤..高血压药物基因多态性分析对安徽皖南地区高血压患者个体化治疗的参考价值[J].中国临床药理学与治疗学,2024,29(1):68-75,8.基金项目
国家自然科学基金(82072370) （82072370）
芜湖市科技局应用基础研究(2022jc66) （2022jc66）
