中国临床药理学与治疗学2024，Vol.29Issue(1)：76-81,6.DOI:10.12092/j.issn.1009-2501.2024.01.008
气管镜下介入联合药物注射治疗中央型非小细胞肺癌疗效与安全性研究
Efficacy and safety of interventional therapy combined with drug in-jection under bronchoscope in the treatment of central non-small cell lung cancer
摘要
Abstract
AIM:To evaluate the efficacy and safe-ty of interventional therapy combined with tumor drug injection under bronchoscope for central non-small cell lung cancer(NSCLC).METHODS:Sixty-four patients who met the test admission criteria were randomly assigned to the experimental group and the control group according to the ratio of 1:1,and were given bronchoscopic interventional thera-py combined with local drug injection of recombi-nant human endostatin combined with platinum-containing dual-drug chemotherapy and platinum-containing dual-drug alone,respectively.The cura-tive efficiency and safety of the two groups were compared.RESULTS:Compared with the control group,the KPS score,dyspnea grading were signifi-cantly improved(P＜0.05).The effective rate of the test group was 78.12％,which was higher than 37.5％in the control group,the difference between the two groups was significant(P＜0.05).Moreover,there was also a significant difference in the 1-year survival rate between the experimental group and the control group(P＜0.05).CONCLUSION:The treatment of central NSCLC by interventional thera-py combined with tumor drug injection through fi-beroptic bronchoscope has obvious clinical efficacy,which can effectively alleviate the clinical symp-toms and improve the quality of life of patients.There is no significant difference in adverse reac-tions between the two groups,and is worthy of popularization and application.关键词
非小细胞肺癌/气管镜/介入治疗/药物注射Key words
non-small cell lung cancer/tracheo-scope/interventional therapy/drug injection分类
医药卫生引用本文复制引用
徐凌,叶伟,吕莉萍,王华..气管镜下介入联合药物注射治疗中央型非小细胞肺癌疗效与安全性研究[J].中国临床药理学与治疗学,2024,29(1):76-81,6.基金项目
医学科研发展基金项目临床与基础研究专项(TB206017) （TB206017）
