中国临床药理学与治疗学2024，Vol.29Issue(1)：82-89,8.DOI:10.12092/j.issn.1009-2501.2024.01.009
胃肠道间质瘤药物治疗和耐药机制研究进展
Research progress on drug treatment and drug resistance mechanism of gastrointestinal stromal tumors
摘要
Abstract
Gastrointestinal stromal tumors(GIST)are the most common mesenchymal-derived tu-mors of the gastrointestinal tract.Tyrosine kinase inhibitors(TKIs)are the cornerstone of GIST thera-py,but mutations in resistance genes pose many problems for treatment,especially the heterogene-ity of KIT resistance mutations.In recent years,with the release of a number of GIST related drug research and experimental results,the great poten-tial of targeted therapy,immunotherapy and com-bination therapy to treat GIST in different direc-tions has been revealed,providing more therapeu-tic directions for GIST.This article will review the experimental research and future direction in re-cent years.关键词
胃肠道间质瘤/药物治疗/耐药机制/研究进展Key words
stromal tumors of the gastrointesti-nal tract/drug therapy/drug resistance mecha-nisms/research progress分类
医药卫生引用本文复制引用
赵全铭,杨满斗,胡义波,苏有橦,普丽,章瑜,李文亮..胃肠道间质瘤药物治疗和耐药机制研究进展[J].中国临床药理学与治疗学,2024,29(1):82-89,8.基金项目
国家自然科学基金(82160563) （82160563）
