3例犬炎性乳腺癌的病理学诊断和组织学分级评价OA

In order to diagnose three cases of clinically suspected canine inflammatory mammary carcinoma,this study employed hematoxylin-eosin(H.E.)staining for histopathological examination of the submitted masses.Immunohistochemical staining using pan-cytokeratin(Pan ck)antibody,cytokeratin 8(CK8)antibody,and von Willebrand factor(VWF)antibody was applied to determine the immunophenotype.The results revealed that the tumors in the three affected dogs exhibited tubular carcinoma,solid carcinoma,cribriform carcinoma,and comedocarcinoma,accompanied by phenomena such as lymphatic vessel dilation and tumor emboli infiltrating lymphatic vessels,consistent with the characteristics of canine inflammatory mammary carcinoma.Immunohistochemical staining confirmed that the tumor originated from glandular epithelium,and numerous tumor emboli were present in lymphatic vessels and blood vessels.Through pathological analysis combined with clinical manifestations,all three cases were diagnosed as canine inflammatory mammary carcinoma.According to the Pena grading criteria,case 1 was classified as grade Ⅲinflammatory mammary carcinoma,while cases 2 and 3 were classified as grade Ⅱ inflammatory mammary carcinoma.The results of this study not only provide reference for the pathological diagnosis of canine inflammatory mammary carcinoma,but also offer theoretical basis for the formulation of clinical treatment plans and prognosis evaluation for cases of canine inflammatory mammary carcinoma.