中国循证儿科杂志2023，Vol.18Issue(6)：424-428,5.DOI:10.3969/j.issn.1673-5501.2023.06.003
延长输注人血白蛋白治疗时间对新生儿胃穿孔术后住院预后的回顾性队列研究
The impact of prolonged human serum albumin infusion treatment in newborns with gastric perforation on hospitalization outcomes:A retrospective cohort study
摘要
Abstract
Background Human serum albumin infusion was empirical therapy after neonatal gastric perforation surgery.It is unclear whether excessive supplementation is beneficial.Objective To investigate whether prolonged human serum albumin infusion treatment in newborns with gastric perforation after abdominal surgery can improve the short-term outcomes.Design Retrospective cohort study.Methods The newborns who received intravenous infusion of albumin(1-2 g·kg-1)after gastric perforation were divided into short course group(≤5 days)and long course group(＞5 days)according to the time of empirical application of albumin.The perinatal condition,main symptoms,signs,and laboratory results before operation,preoperative and postoperative complications,surgical condition(perforation site,pathological findings,etc.),postoperative treatment and hospital prognosis were collected.Main outcome measures Postoperative nutritional status and hospitalization outcomes.Results There were 37 cases in the short course group and 26 cases in the long course group.There was no significant difference in perinatal general condition,preoperative symptoms and signs,preoperative laboratory results,complications,perforation location and pathological findings between the two groups(P＞0.005).In the short course group compared with the long-term treatment group,the gestational age was younger(P=0.005),the proportion of diabetes in pregnancy was higher(P=0.034),the age of onset was earlier(P=0.035),the age of operation was younger(P=0.035),the total amount of albumin infusion after operation was less(P=0.000),the 70％total enteral nutrition time was longer(P=0.019),the total enteral nutrition time was longer(P=0.005),and the hospital stay was shorter(P=0.012).However,there was no significant difference in secondary operation,length of stay,status of improvement or curation and weight at discharge between the two groups.Neonates with the difference of birth weight＜250 g,gestational age＜1 week and age of onset＜1 d in short course group and long course group were matched at 1∶1.Twenty-two cases were included in each group.There was no significant difference in postoperative antibiotic use time,postoperative invasive respiratory support,times of plasma transfusion,gastrointestinal decompression time,fistulostomy tube indwelling time,postoperative enteral feeding time,70％total enteral nutrition time,total enteral nutrition time,secondary operation,hospital stay and discharge weight between the two groups.Conclusion Prolonged treatment time of human serum albumin infusion is not beneficial to the nutritional status and hospitalization outcomes of newborns with gastric perforation.关键词
胃穿孔/白蛋白/预后/新生儿Key words
Gastric Perforation/Human serum albumin/Prognosis/Newborn引用本文复制引用
唐烁,王政力,崔梦莺,韦欢,朱婷,刘煜,刘伟,包蕾,史源..延长输注人血白蛋白治疗时间对新生儿胃穿孔术后住院预后的回顾性队列研究[J].中国循证儿科杂志,2023,18(6):424-428,5.基金项目
儿童发育疾病研究教育部重点实验室基础研究一般项目:GBRP-202107 （）
中国博士后科学基金71批面上项目基金:2022MD713716 （）
