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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de Mesy Bentley Ye Shu Yuting Liu Elysia Masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.Schwarz Shuting Sun Chao Xie

Bone Research2023，Vol.11Issue(4)：P.751-763,13.

Bone Research2023，Vol.11Issue(4)：P.751-763,13.DOI:10.1038/s41413-023-00287-4

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Youliang Ren ¹Jason Weeks ¹Thomas Xue ¹Joshua Rainbolt ¹Karen L.de Mesy Bentley ²Ye Shu ¹Yuting Liu ¹Elysia Masters ¹Philip Cherian ³Charles E.McKenna ⁴Jeffrey Neighbors ⁵Frank H.Ebetino ⁶Edward M.Schwarz ¹Shuting Sun ³Chao Xie¹

作者信息

1. Center for Musculoskeletal Research,University of Rochester Medical Center,Rochester,NY 14642,USA Department of Orthopaedics,University of Rochester Medical Center,Rochester,NY 14642,USA
2. Center for Musculoskeletal Research,University of Rochester Medical Center,Rochester,NY 14642,USA Department of Orthopaedics,University of Rochester Medical Center,Rochester,NY 14642,USA Department of Pathology and Center for Advanced Research Technologies,University of Rochester Medical Center,Rochester,NY 14642,USA
3. BioVinc,LLC,Pasadena,CA 91107,USA
4. Department of Chemistry,University of Southern California,Los Angeles,CA 90089,USA
5. Department of Pharmacology,Pennsylvania State University,Hershey,PA 17033,USA
6. BioVinc,LLC,Pasadena,CA 91107,USA Department of Chemistry,University of Rochester,Roche
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摘要

关键词

implant/infection/overcome

分类

医药卫生

引用本文复制引用

Youliang Ren,Jason Weeks,Thomas Xue,Joshua Rainbolt,Karen L.de Mesy Bentley,Ye Shu,Yuting Liu,Elysia Masters,Philip Cherian,Charles E.McKenna,Jeffrey Neighbors,Frank H.Ebetino,Edward M.Schwarz,Shuting Sun,Chao Xie..Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis[J].Bone Research,2023,11(4):P.751-763,13.

基金项目

supported by grants from the National Institutes of Health(SBIR R44 AI125060,NIAMS P50 AR072000,and NIAMS P30 AR069655)。（SBIR R44 AI125060,NIAMS P50 AR072000,and NIAMS P30 AR069655）

Bone Research

OACSCDMEDLINE

ISSN：2095-4700

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